Single crystalline porous organic polymers are a kind of organic porous materials with high crystallinity and stability driven by non-covalent bonds and covalent bonds. Such well-defined material has the advantages of large specific surface area, low density, tunable structure, adjustable pores and modifiable reaction sites, etc. It has attracted much attention due to its diverse synthesis strategies and wide range of applications. In this review, the synthesis strategies and principles of common single crystalline porous organic polymer materials are summarized, and the recent progress of single crystalline porous organic polymer materials is also introduced briefly in three parts, including modular design concepts, structural control and crystal growth of porous organic polymer materials, and their potential applications in the detection and adsorption of environmental pollutants, gas separation and storage, photoelectronic and chemical sensing, etc. After that, the authors look forward to the precise synthesis and performance development of single crystalline organic polymer materials.