(1.School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China) (2.National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China) (3.Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou 510006, China)
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DOI:
10.7502/j.issn.1674-3962.2012.06.02
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Abstract:
Because of the special morphology and characterization, micro and nano bioactive glass caused much attention by researchers, but the morphology of micro and nano bioactive glass on cell performance has been underappreciated and underinvestigated. The special morphology of micro and nano bioactive glass was synthesized by the Sol gel method combined with the template bionic. Human mesenchymal stem cells (hMSCs) were seeded on bioactive glass for 6 days and 10 days in vitro for alkalic phosphatase (ALP) activity and 5days for osteogenic gene expression analysis. Based on the results of ALP activity and osteogenic gene expression analysis, the responses of hMSCs to the SBG exhibited a higher degree of osteogenic differentiation than those on IBG in vitro. This work will provide a reference for design of specific morphology of the bioactive glass in the future.