(Department of Materials Science and Engineering, Jinan University, Guangzhou 510632，China)
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DOI:
10.7502/j.issn.1674-3962.2012.09.05
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Abstract:
Materials implanted in the body would inevitably lead to host response, promoting or inhibiting tissue healing. The degradation products of biodegradable materials in the body will change with time, resulting in different host responses and further affecting tissue healing. Therefore, the mechanism of promoting or inhibiting tissue healing becomes the theoretical basis for the design and preparation of novel biomedical polymer materials. Chitosan is one of the ideal medical polymer materials, but we still do not know the effect mechanism of chitosan degradation process on tissue repair in vivo. So it will not be able to design chitosanbased materials with excellent performance. This review does not lay out the progress of the chitosanbased biomaterials applied in bone tissue engineering, but focuses on the complexity of chitosan applications for bone tissue engineering, furthermore investigates the problems needed to be solved for chitosan used in bone tissue engineering.