1. Orthopaedic Research Institute, First Affiliated Hospital of Sun Yatsen University, Guangzhou 510080, China）
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DOI:
10.7502/j.issn.1674-3962.2012.09.06
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Abstract:
Traditional biomaterials for hard tissue repair in composition and structure are hugely different with human bone tissue. The repairing process of these materials is basically a passive “filling” process when implanted in the body. Because new bone formation and material degradation rate do not match well enough, it is difficult to achieve the real “biological fusion”, and this restricted the use of materials in orthopaedic clinical application. Therefore, design and preparation of advanced third generation biomaterials for hard tissue repair with “active repair function” and “controlled biological response characteristics” has become the new demand of orthopaedic clinical application and future research direction. This paper introduced main research methods for bone regeneration mechanisms of advanced biomaterials for hard tissue repair, and it also summarized the current research results of interactions between these biomaterials and host cells in host microenvironment, and interactions between the biomaterials and host defense responses in the process of bone regeneration.