(Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China)
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DOI:
10.7502/j.issn.1674-3962.2013.09.04
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Abstract:
Superconducting Quantum Interference Device (SQUID) is a kind of ultra-sensitive flux detector based on macroscopic quantum interferencephenomenon of Josephson junctions. The principle of SQUID and advantages of its application in low-field nuclear magnetic resonance (NMR) &imaging (MRI) technologies are introduced, and some important experimental results are reported here. We built a low-field NMR&MRI system and obtained highly improved 1H proton FID&Spin echo spectra. Pure J-coupling spectrum of 2,2,2-Trifluoroethyl was also measured and agreed well with high-field NMR results. In addition, we tried and successfully obtained 1D and 2D MRI images of water phantoms and bio-samples. The influence of 8nm Fe3O4 magnetic nanoparticles on longitudinal relaxation time of water was studied. Based on this property, we illustratedT1-contrast enhanced 2D imaging of water phantoms by using magnetic nanoparticles, which show evident contrast variation under different pre-polarization times.