(School of Biology and Medicine Engineering, Southeast University, Nanjing 210096, Jiangsu)
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DOI:
10.7502/j.issn.1674-3962.2013.10.05
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Abstract:
Effective gene delivery is critical for gene therapy, and depends on the development of effective and safe delivery carrier. Ideal carrier of gene delivery should possess plenty of properties, including high delivery efficiency, low cytotoxicity, less effect on physiological effect of normal cells, and ease of use and duplication. Nanomaterials have potential applications in the field of drug and gene delivery due to unique physical and chemical properties. Magnetic nanoparticles with nano-effect and superparamagnetic properties are very promising delivery carrier. We briefed the key factors affecting the gene delivery of MNPs, including the types, size and surface properties of nanoparticles and external magnetic field. The current applications and challenges of MNPs in gene delivery was summarized and discussed.