?State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China
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DOI:
10.7502/j.issn.1674-3962.2014.04.03
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Abstract:
Commodity polymers with high functionality and performance are widely applied in the field of biomedical supplies and equipment. As one of most important biomaterials, hemocompatibility is a key challenge. The hemocompatibility of commodity polymers can be improved with chemical and biological method, including bulk and surface modification in general. Bulk modification was obtained by melt grafting and blending, while surface modification could be achieved through (i) surface passivation with hydrophilic layers, (ii) immobilization of bioactive molecules and (iii) formation of biomimetic membrane. The investigation of hemocompatibility was mainly concentrated on plasma protein adsorption, platelet adhesion and hemolysis of red blood cell. This report presents an overview on hemocompatibility of modified commodity polymers, with focus on the progress achieved by our research group in Changchun Institute of Applied Chemistry in recent years.