State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
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DOI:
10.7502/j.issn.1674-3962.2015.03.04
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Abstract:
The development of novel vaccines posed several challenges for the study of adjuvant. To overcome the incapability of conventional adjuvant on cellular immune response, a serious of uniform sized micro/nano-particles (MP/NPs) with different physio-chemical properties (size, charge or surface group) were prepared by using the polymer materials with good biocompatibility. MP/NPs could improve the antigen internalization, antigen presentation and T cell proliferation, which were catering for the preventive or therapeutic effect against the infectious diseases or cancer. To complement the nasal immune adjuvant, a novel thermal-sensitive hydrogel, which can undergo sol-gel transition at body temperature were developed by using the chitosan with good bioadhesion. This hydrogel could significantly prolong the antigen residence time, enhance the antigen penetration, and activate the immune cells, thus inducing strong immune responses and expanding the conventional vaccination by injection. The MP/NPs and hydrogel based adjuvant exhibited a promising era for the novel vaccine delivery system.