National Engineering Research Center for Biomaterials, Sichuan University
Keywords:
-
CLC:
PACS:
-
DOI:
10.7502/j.issn.1674-3962.2015.07.13
DocumentCode:
Abstract:
Since most living tissues are composed of repeating micro-units with highly complex organizational structure, one of the major challenges in tissue engineering is to reproduce the architectures and functional properties of these micro-units in vitro. Microscale tissue engineering is a new emerging field which can precisely control the cellular microenvironment by the regulation of the microscopic geometry of scaffold using modern microfabrication technology. Accordingly, the simulation of natural tissues with non-homogeneous and isotropic heterosexual artificial can be directed and promoted on the microscale level. Through fabrication the micro-units and assembly by the “bottom-up” approach, construction the engineered tissue with complicated structure became possible .Therefore the mciroscale tissue engineering could provide us a new pathway and idea for the tissue engineering. In this paper, an overview of microfabrication technologies and construction approaches common used in microscale tissue engineering were presented, and the future applications and challenges of this field were discussed. Meanwhile, a bottom-up approach to direct the assembly of cell-laden microgels to generate tissue constructs was illustrated.