(College of Medicine and Nursing, Dezhou University，Dezhou 253023,China)
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DOI:
10.7502/j.issn.1674-3962.2016.03.10
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Abstract:
Superparamagnetic iron oxide nanoparticles (SPIONs) have shown immense potential to contrast agents for the magnetic resonance imaging diagnosis and cancer theranostics. There are specific expression of some surface markers in the tumor cell surface, so the molecule probe with magnetic nanoparticles as the core with a specific molecular markers on the surface of the tumor cells can identify the tumor and form a magnetic resonance imaging.The surface grafted with various targeting ligands affects the particles tissue distribution and pharmacokinetics. The bioavailability of drug in the tumor site is improved through the high permeability and doubled targeting magnetic field,reducing the toxicity to normal cells and increasing tumor local drug concentration.SPIONs have the very high magnetocaloric effect, which can kill tumor cells by heating, and the side effects are smaller than that of radiotherapy and chemothera.Functionalized SPIONs will become popular negative contrast materials for magnetic resonance imagingbased diagnosis and therapy. This review aims to focus on the ability of SPIONs used in the field of cancer diagnosis and targeting therapy as well as the synthesis,modification and the characteristics of SPIONs.