Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences & Medical Engineering, Southeast University
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DOI:
10.7502/j.issn.1674-3962.2016.08.01
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Abstract:
Magnetic nanoparticles (MNPs)-mediated targeted magnetic hyperthermia (TMH) is a rapid-developing tumor therapy in vivo. Based on its curative effect, high safety and less side effects, the therapy may widely receive enormous attention in further clinical applications. However, it has rather challenging in the MNPs-based passive or active targeted hyperthermia therapy by intravenously administration in vivo and their further enhanced therapy efficacy. In this regard, several basic scientific issues and key factors, such as the improved monodispersity of MNPs and their magnetic-induced heating effect, the increased MNPs accumulation in target tissues, the synergistic hyperthermia and chemotherapy effect, the focused heat induction and the multi-modal imaging-guided precise diagnostics, should be especially considered. Here we begin our review with the goal of describing controlled synthesis and surface modification of the MNPs with high performance, and then give a discussion on current key considerations in the MNPs-mediated TMH in vivo. Its superiority and disadvantages which are to be conquered are also described here. Finally, we get a perspective for its promising therapy in future clinical application.