Since the study of High-entropy alloys (HEAs), it possesses excellent properties, currently attracting increasing researcher interest. It is now generally accepted that the definition of high-entropy alloy is composed at least five principal elements with equimolar ratio or approximately equimolar ratio. Meanwhile, the composition of each element varies from 5 to 35 %. The configuration entropy, mixing enthalpy, atomic radius difference, valence electron concentration and other physical parameters were calculated, combining with CALPHAD phase diagram simulation and first-principles density functional theory (DFT) and AIMD simulation, to predict the phase structure of High-entropy alloys. At present, three types of high-entropy alloys are mainly composed of FCC, BCC and HCP. HCP high-entropy alloys are scarce and mainly consist of rare earth elements and precious metal elements HCP high entropy alloy.In recent years, it has been found that FCC high-entropy alloys can also be transformed into HCP high-entropy alloys through special treatment methods (such as high pressure). In this paper, the structure, phase formation and properties of HCP high-entropy alloys are reviewed.