In view of the in-stent restenosis (ISR) problem in clinic, the team led by Prof. Ke Yang in the Institute of Metal Research, Chinese Academy of Sciences has developed a new class of Cu-bearing metal materials for stent application (316L-Cu stainless steel and L605-Cu cobalt based alloy). This paper reviews the recent advances of the research team regarding this new class of Cu-bearing metal stent materials. The experimental results showed that these Cu-bearing metal stent materials can effectively promote the proliferation and migration of endothelial cells and decrease the apoptosis rate, whereas on the contrary inhibite the proliferation and migration of arterial smooth muscle and promote its apoptosis. More than this, they also can reduce the adhesion of platelets on the metal surface, prolong the dynamic coagulation time, and thus reduced the tendency of thrombosis. In addition, the new stent materials also have excellent biocompatibility. The in vivo studies show that the Cu-bearing stainless steel stent implantation in animals have excellent biocompatibility and can obviously promote endothelialization, inhibit thrombosis, and ultimately inhibit the occurrence of ISR. Consequently, these new Cu-bearing metal materials are expected to be a new generation coronary stent materials with the function of reducing occurrence of ISR.