The influence of die deformation rates (range from 2 mm/s to 10 mm/s) on microstructure and mechanical properties of TC18 titanium alloy was investigated. The results showed that the low die deformation rate promoted the dynamic recrystallization of TC18 titanium alloy. The basketwave microstructure with broken grain boundary α phase was formed. The fractography characterization showed ductility dimple and the forged sample possessed excellent ductility and KIC fracture toughness. While only the dynamic recovery occurred during high die deformation rate, which produced the basketwave microstructure with straightness grain boundary α phase. The fractography characterization showed brittle cleavage and the forged sample possessed low ductility and KIC fracture toughness. The strength properties have insensitivity on the die deformation rates.