1. Jiangsu Key Laboratory for Biomaterials and Devices, State Key of Laboratory Bioeletronics, School of Biological Sciences & Medical Engineering, Southeast University 2. Collaborative Innovation Center of Suzhou Nano-Science and Technology
Micro-nano scaffolds are typically a type of bionic scaffold with micro- or nano-scale features structurally. Compared with traditional scaffolds, micro-nano scaffolds have excellent surface effects and size effects, and thus exhibit great superiority in the treatment of various diseases. Especially, micro-nano scaffold-stem cell complex can be widely used in tissue engineering repair, tumor treatment, and other fields when combined with stem cells. However, the preparation methods, material types, surface morphology, scale and internal structure sequence of micro-nano scaffolds are all crucial factors involved in the therapeutic effect of micro-nano scaffold-stem cell complex. Therefore, this paper intends to review the preparation of micro-nano scaffolds and the research status of micro-nano scaffolds in stem cell therapy and to prospect its clinical application.