It is of great significance for energy industry, chemical industry, environmental protection and sustainable development of using heterogeneous catalysts to catalyze chemical reactions. Extensive applications of metal-organic frameworks (MOFs) and their derivatives are expanded in heterogeneous catalysis due to their large specific surface area, dispersed active centers, extremely high porosity and adjustable pore structure. According to the sources of active sites of MOFs, we summarize some relative work of MOFs in heterogeneous catalysis as follows: MOFs themselves do not have a catalytic activity, and only as a catalyst carrier; the functional groups modified in MOFs have catalytic activity; MOFs with unsaturated metal nodes have catalytic activities, and can promote the reaction. Finally, we look forward to the future research and application of MOFs in the heterogenous catalysis. We hope this review will help researchers understand more about the research progress of MOFs materials in the heterogeneous catalysis, providing some meaningful reference.