1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201600, China
2. Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine,Research Base of Textile Materials for Flexible Electronics and Biomedical Applications,China Textile Engineering Society, Institute of Functional Materials, Shanghai 201600, China
A novel polyurethane material—poly(oxime urethane), which with good degradability and 3D printing ability, was developed for biomedical applications. The biodegradable polycaprolactone based poly(oxime urethane) (PCL-PU) was synthesized by two-step polycondensation of polycaprolactone diol, isophorone diisocyanate and dimethylglyoxime. The structure and properties of PCL-PU were characterized by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (1H-NMR), gel permeation chromatography (GPC), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), rheological measurement, enzymatic degradation test, uniaxial tensile test and compression test. The results showed that PCL-PU was successfully synthesized. PCL-PU possessed good thermal stability, degradability and mechanical properties. After degradation for 7 d, the degradation rate of PCL-PU reached (44.3±12.9)%. At the same time, PCL-PU possessed good processibility and could be readily 3D printed at 99 ℃. This material was expected to be applied in the field of biomedicine such as tissue engineering scaffolds.