(Suzhou Nanotechnology Collaborative Innovation Center, Institute of Functional Nanotechnology and Soft Matter, Soochow University, Suzhou 215123, China)
Against the backdrop of increasing public health awareness, two-dimensional nanomaterials have been extensively explored in various biomedical applications due to their unique anisotropy and large specific surface area properties. Layered double hydroxides (LDHs), also named hydrotalcite nanomaterials, have multiple physicochemical advantages, including excellent biocompatibility, pH-sensitive biodegradability, highly tunable chemical composition and structure, and easy to form composites with other materials, showing great promise in biomedical applications. In this review, we summarize recent advances in LDHs-based nanomaterials for biomedical applications. First, the material definition of LDHs-based nanomaterials and their preparation methods are discussed. We then systematically describe the great potential of LDHs for biomedical applications, focusing on comprehensive elaboration in biological fields such as cancer therapy, antibacterial, tissue engineering repair, and biosensing. Finally, building on the current state of the art, we provide insights into the challenges and future development strategies of this rapidly emerging field, which we expect to advance into biomedical applications that benefit patients.