Two-dimensional polymers (2DPs) are emerging crystalline 2D organic material comprising free-standing, single-atom/monomer-thick, planar, and covalent networks with long-ranging structural order. Benefiting from the diversity of monomers and connection, several strategies have been developed to synthesis 2DPs. Among all the strategies, interfacial synthesis was applied to fabricate large scale single-or multi-layer crystalline 2DPs, which promoted the application of 2DPs in electric, catalyst and energy field. At present, the interfaces for the synthesize of two-dimensional polymers include gas-liquid interface, liquid-liquid interface, gas-solid interface, and liquid-solid interface. In this review, we summarize the development of interfacial synthesis strategy and present the trends regarding to the interfacial synthesis of CC based-conjugated 2DPs. With the development of 2DPs, the synthesis of CC bondlinked fully conjugated polymers using irreversible reactions has attracted extensive interest. Since most of the currently synthesized CC-linked 2DPs are in powder form, their morphology limits the application of 2DPs. Compared to powdered products, 2D polymer films offer unique advantages in a variety of applications. Thanks to the versatility and designability of interfacial synthesis strategies, the synthesis of fully conjugated 2D polymer films is expected to be achieved through synthetic design of interfacial synthesis strategies, laying the foundation for the development of highly stable and high performance 2D polymer films.