1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China
2. School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China
Biomaterials for bioelectronics are susceptible to the adhesion of proteins/cells, which will affect the chronic stability of devices. Here, Anti-fouling parylene films were studied and prepared to resist the adhesion of proteins or cells. Bromine functionalized parylene film was first deposited on parylene, and then, atom transfer radical polymerization was conducted to modify parylene with zwitterions. Three different types of zwitterionic polymers, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), poly(2-methacryloyloxyethyl sulfobetaine) (PMSB) and poly(2-methacryloyloxyethyl carboxybetaine) (PMCB) were used to modify parylene, and their properties were studied. It was observed that PMPC-functionalized parylene showed the best antifouling properties. Moreover, the PMPC-functionalized parylene was also utilized to fabricate patterned bio-platform by a lithography-combined microfabrication for spatially guiding neural cell attachment. These zwitterionic functionalized parylene films, which can resist anti-inflammatory cells and control the growth of nerve cells, have a promising future in the field of bioelectronic devices.