The development of copper matrix composites promises to comprehensively enhance the mechanical properties and functional characteristics, such as electrical and thermal conductivity, of copper and copper alloys. Graphene possesses excellent mechanical and physical properties and is regarded as an ideal reinforcement material for copper matrix composites. The interface properties between graphene and copper determines the overall performance of the composites. Enhancing the interfacial adhesion of graphene/copper through interface regulation has become a research hotspot currently. This review summarizes various regulation strategies for the graphene/copper interface in recent years, including graphene defect designing, carbon-carbon hybrid reinforcements, metal and ceramic nanoparticle-modified graphene,and in-situ grown graphene and graphene complex reinforcements. It systematically discusses the mechanisms by which interface regulation influences the mechanical properties, electrical conductivity and thermal conductivity of the composites. Moreover, the application prospects of highperformance composites developed by interface regulation strategies and future research directions are also provided.