文章信息/Info

Title:

Recent Progress in Development of Microcarrier Materials for Environmental Responsive Controlled Release

作者:

巨曉潔; 謝銳; 褚良銀

(四川大學化學工程學院, 四川 成都610065)

Author(s):

JU Xiaojie;  XIE Rui;  CHU Liangyin

 (School of chemical Engineering, Sichuan University, Chengdu 610065, China)

關鍵詞:

微載體; 環境響應型; 控制釋放; 智能微囊; 功能材料

DOI:

10.7502/j.issn.1674-3962.2012.02.06

文獻標志碼:

A

摘要:

環境響應型智能微載體材料可以響應溫度、pH值、磁場、化學物質等環境刺激的微小變化，實現物質的自律式控制釋放，在藥物送達、酶和細胞固定化、分離純化等領域顯示出突出的優越性，具有廣泛應用前景。綜述了環境響應型控制釋放微載體材料的研究進展，介紹了“開-關模式”控釋微囊和“突釋模式”控釋微囊等環境響應型控釋微載體材料的研究新進展，著重介紹了溫度響應型、血糖濃度響應型、離子識別響應型“開-關模式”控釋微囊以及溫度響應型、pH響應型、離子識別響應型“突釋模式”控釋微囊的制備與性能方面的研究新成果。目前，環境響應型智能微載體材料仍多處于基礎研究階段，還需要進一步系統深入研究和開發完善。

Abstract:

Environmental stimuli�瞨esponsive smart microcarrier materials, which can realize self�瞨egulated controlled release in response to the change of temperature, pH, magnetic field and special chemicals in external environment, exhibit excellent superiorities in various fields, such as drug delivery, immobilization of enzyme and cells, and separation and purification of chemicals. The progress in development of environmental stimuli responsive smart microcarrier materials are reviewed, in which the smart gating microcapsules for controlled release and smart microcapsules for controlled burst�瞨elease are introduced. Especially, the thermo�瞨esponsive, glucose�瞨esponsive and ion recognition smart gating microcapsules for controlled�瞨elease as well as the thermo�瞨esponsive, pH responsive and ion�瞨ecognition smart microcapsules for burst release are introduced and reviewed systematically. At present, environmental stimuli responsive smart microcarrier materials are still in the basic research stage and need intensive study and further development.