文章信息/Info

Title:

Biomimetic Functionalized Bone Repair Materials

作者:

杜昶; 趙娜如; 葉建東; 陳曉峰; 王迎軍

(1.華南理工大學材料科學與工程學院，廣東 廣州 510640)��
（2.華南理工大學 國家人體組織功能重建工程研究中心，廣東 廣州 510006)

Author(s):

DU Chang;  ZHAO Naru;  YE Jiandong;  CHEN Xiaofeng;  WANG Yingjun

(1.School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China）��
(2.National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China）

關鍵詞:

骨修復材料; 生物礦化; 仿生合成

DOI:

10.7502/j.issn.1674-3962.2012.05.01

文獻標志碼:

A

摘要:

由腫瘤、炎癥及各類創傷而導致的骨組織壞死、病變、缺失及骨折是臨床多發病癥，自體骨移植雖然是臨床治療的“金標準”，但由于供體受限而很難滿足需求。通過對天然骨本身的成分、結構特性及礦化過程的模仿，應用先進材料制備技術，特別是納米技術，對材料的組成、結構進行設計與調控，獲得仿生型骨修復材料或者對傳統材料進行仿生功能化修飾，以滿足臨床對病損或缺失的骨組織進行有效修復和功能重建具有重要意義。闡述了仿生功能化骨修復材料的相關研究，主要包括類骨鈣磷納米礦物的合成，有機分子模板對納米礦物尺寸和形貌的調控，以及仿生多孔結構支架的構建等。

Abstract:

Bone defect and bone fracture are common clinical implications due to bone tumor resection, bone necrosis, osteitis and various traumas. Transplantation of autograft that comes from a healthy site in patient to the defect site is the gold standard treatment but the donor shortage limits its application. Mimicking the compositional and structural characteristics of bone and its biomineralization process, biomimetic functionalized bone repair materials can be produced with advanced materials synthesis and processing techniques, in particular nanotechnology development to a precise modulation. This manuscript focuses on the synthesis of nanoscale calcium and phosphate containing minerals, the control of organic molecular templates on the size and morphology of bone like minerals, as well as the construction of biomimetic porous scaffold.