文章信息/Info

Title:

Preparation and Properties Improvement of Biomaterials Scaffolds with Various Porous Structures

作者:

羅會(huì)濤; 趙婧; 范興平; 崔文國(guó); 段可; 馮波; 李孝紅; 翁杰

(西南交通大學(xué)材料科學(xué)與工程學(xué)院 材料先進(jìn)技術(shù)教育部重點(diǎn)實(shí)驗(yàn)室，四川 成都 610031)

Author(s):

DUAN Ke;  FENG Bo;  LI Xiaohong;  WENG Jie

(Key Laboratory of Advanced Technologies of Materials (MOE), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China)

關(guān)鍵詞:

組織工程; 生物材料; 多孔支架; 制備技術(shù); 性能優(yōu)化

DOI:

10.7502/j.issn.1674-3962.2012.05.04

文獻(xiàn)標(biāo)志碼:

A

摘要:

多孔支架是組織工程應(yīng)用中的關(guān)鍵環(huán)節(jié)，類似細(xì)胞外基質(zhì)的作用，支撐細(xì)胞的粘附和隨后細(xì)胞向組織的衍化。雖然目前已采用多種制備技術(shù)研發(fā)出大量的多孔支架，但是多孔生物材料支架的制備和性能優(yōu)化，仍然是組織工程支架領(lǐng)域的研究熱點(diǎn)。結(jié)合實(shí)驗(yàn)室工作，綜述了多種制備不同類型多孔結(jié)構(gòu)生物材料支架的制備技術(shù)，主要包括顆粒和纖維堆積型支架、泡沫浸漬法支架和顆粒制孔支架等的制備技術(shù)，并闡述了這些制備技術(shù)對(duì)多孔結(jié)構(gòu)支架的孔結(jié)構(gòu)、貫通性和力學(xué)性能的改善效果。其目的旨在提供滿足組織工程需求的多孔生物材料支架。

Abstract:

The porous scaffold is a key factor in the application of tissue engineering. Porous scaffolds which play the role of extracellular matrix similarly provide space for cell adhesion and the subsequent derivation of cells to organization. At present, although a large number of porous scaffolds have been fabricated by various preparation technologies, preparation technologies and performance optimizations of porous biomaterials scaffolds is still a hot topic in the field of tissue engineering. Combined with the work in our laboratory, this paper reviewed a variety of preparation technologies (including particle accumulation method, fiber accumulation method, foam immersion method, particle leaching method, etc.) of biomaterials scaffolds with various types of porous structure and illustrated the effect on pore structure, connectivity and mechanical property, etc. The aim is to provide a porous biomaterials scaffold to satisfy the need of tissue engineering.