[1]蔡曉巍,阮曉博,房坤,等.生物醫學診療用磁性微納材料[J].中國材料進展,2012,(6):001-6.[doi:10.7502/j.issn.1674-3962.2012.06.01]
CAI Xiaowei,RUAN Xiaobo,FANG Kun,et al.Biological Magnetic Micro/Nano Materials for Theranostics[J].MATERIALS CHINA,2012,(6):001-6.[doi:10.7502/j.issn.1674-3962.2012.06.01]
點擊復制
生物醫學診療用磁性微納材料(
)
中國材料進展[ISSN:1674-3962/CN:61-1473/TG]
- 卷:
-
- 期數:
-
2012年第6期
- 頁碼:
-
001-6
- 欄目:
-
前沿綜述
- 出版日期:
-
2012-06-25
文章信息/Info
- Title:
-
Biological Magnetic Micro/Nano Materials for Theranostics
- 作者:
-
蔡曉巍; 阮曉博; 房坤; 楊芳; 顧寧
-
（1. 東南大學 生物電子學國家重點實驗室，江蘇 南京 210009）
（2. 江蘇省生物材料與器件重點實驗室，江蘇 南京 210096）
- Author(s):
-
CAI Xiaowei; RUAN Xiaobo; FANG Kun; YANG Fang; GU Ning
-
(1. State Key Laboratory of Bioelectronics，Southeast University, Nanjing 210009, China)
(2. Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210096, China)
-
- 關鍵詞:
-
磁性微氣泡; 診療學; 微納復合結構
- DOI:
-
10.7502/j.issn.1674-3962.2012.06.01
- 文獻標志碼:
-
A
- 摘要:
-
磁性微氣泡是由包膜微氣泡和磁性納米粒子組成的微納復合結構，由于其具有超聲對比劑和核磁共振對比劑的雙重特性，已被應用于雙模造影領域。聲致穿孔現象（Sonoporation）使得磁性微氣泡能介導多種生物學效應，使其在藥物輸運和基因轉染等方面有潛在的應用價值，而磁性微氣泡與各種生物分子（抗體、腫瘤標記物等）的偶聯，又擴展了磁性微氣泡的應用領域，可用于分子影像診斷和靶向治療腫瘤等方面，可以說磁性微氣泡是新一代的生物醫學診療用磁性微納材料�？偨Y了磁性微氣泡的制備方法，磁性納米顆粒與微氣泡的結合方式，磁性微氣泡的功能擴展，以及磁性微氣泡在生物醫學診療領域的實驗研究，最后對磁性微氣泡在未來的發展方向提出了一些構想，展望了磁性微氣泡在診療學上廣闊的應用前景。
- Abstract:
-
Magnetic microbubble is a micro/nano binary structure composed of encapsulated microbubble and magnetic nanoparticles. Magnetic microbubbles have been used in dualmode imaging for the double properties of ultrasound imaging and magnetic resonance imaging. Sonoporation makes magnetic microbubbles to conduct enormous bioeffects, which have great potential application value in drug delivery and gene transfection. The coupling of magnetic microbubbles to other biomolecules (antibodies, tumor markers and so on) expands the applications of magnetic microbubbles, such as molecular imaging and targeted tumor therapy. So it is proposed that magnetic microbubbles can be potentially applied as a new generation of biological magnetic micro/nano materials for theranostics. This review summarizes the methods to generate magnetic microbubbles, the forms of nanoparticles binding to microbubbles, the functional expanding of magnetic microbubbles and the experimental studies of magnetic microbubbles for biomedical theranostics. In the end, this review raises some ideas of the future development for magnetic microbubbles, and looks forward to the extensive prospects of magnetic microbubbles for theranostics.
更新日期/Last Update:
2012-07-26