文章信息/Info

Title:

Intelligent Responsive Polymeric Particles and Their Interactions with Cells

作者:

張文晶; 高長有

（浙江大學高分子科學與工程學系 教育部高分子合成與功能構(gòu)造重點實驗室，浙江 杭州 310027）

Author(s):

ZHANG Wenjing;  GAO Changyou

（MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of  Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China)

關(guān)鍵詞:

智能響應(yīng); 微粒; 基因/藥物傳遞; 聚合物; 微粒與細胞相互作用

DOI:

10.7502/j.issn.1674-3962.2012.06.04

文獻標志碼:

A

摘要:

智能響應(yīng)型材料能夠感受來自外界的刺激，導致某些物理或者化學性能發(fā)生顯著的變化，因而有著廣泛的研究和應(yīng)用，尤其是在生物醫(yī)用材料領(lǐng)域。除傳統(tǒng)的溫度、光、pH、磁響應(yīng)方式以外，主要綜述了幾種生物信號響應(yīng)型材料，例如生物分子、酶、葡萄糖，以及多重響應(yīng)型材料；著重介紹用作基因或藥物載體的材料。關(guān)注不同響應(yīng)方式的智能材料與細胞之間的相互作用，包括智能響應(yīng)型微粒的胞吞、胞內(nèi)轉(zhuǎn)運、細胞內(nèi)的分布以及響應(yīng)，和微粒的響應(yīng)性變化過程比如體積的膨脹收縮，而非材料本身性質(zhì)與細胞的相互作用。這些結(jié)果有利于在細胞和亞細胞層次上理解響應(yīng)性材料在基因和藥物控釋中的生物相容性等問題，從而更好地設(shè)計載體材料。

Abstract:

Intelligent responsive materials exhibit abrupt changes of physical and/or chemical properties in response to external stimuli. This kind of materials is of great importance in both basic researches and applications, especially in the field of biomedical materials. Besides the traditional photo��, pH��, magnetic�瞨esponsive materials, this article briefly summarizes materials responding to several types of biological signals including enzymes, glucose and other biomolecules. The materials with multi�瞨esponsive properties are emphasized with respect to the applications for gene and drug delivery. New breakthroughs are introduced on the interactions between the intelligent materials and cells, such as cellular uptake, intracellular transportation and distribution as well as responsivity. The importance of specific stimuli�瞨esponsivity such as volume expansion and contraction is envisaged in terms of cells�瞤articles interaction. This would be intriguing to understand the biocompatibility and some other issues of the stimuli�瞨esponsive particles, which in turn can guide the design of delivery carriers of better biological performance.��