文章信息/Info

Title:

Study on the Rheological Properties of Injectable Calcium Phosphate Cement

作者:

陳芳萍; 劉昌勝

（華東理工大學 超細材料制備與應用教育部重點實驗室，上海 200237）

Author(s):

CHEN Fangping; LIU Changsheng

（Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China）

關鍵詞:

可注射; 磷酸鈣骨水泥; 流變性能; 動態頻率掃描; 動態時間掃描

DOI:

10.7502/j.issn.1674-3962.2012.09.01

文獻標志碼:

A

摘要:

采用高級流變擴展系統研究了添加劑種類及其含量對可注射磷酸鈣骨水泥(ICPC)流變特性的影響。采用穩態流動實驗表征漿體的靜態粘度，用觸變環面積、應力降低率和屈服應力表征ICPC漿體的觸變性，并進行動態頻率掃描和動態時間掃描實驗動態監測ICPC的粘、彈、塑性變化規律以及水化反應過程流變參數的依時性。結果表明：添加劑并不改變ICPC的〖JP〗粘彈性。水溶性高分子化合物的加入提高了ICPC的粘度和觸變性，利于整個體系的穩定；添加劑不同程度上提高了ICPC剪切后的網絡結構恢復能力和穩定性，尤其以黃原膠和幾丁糖最為明顯。在此基礎上，評估了加入黃原膠后ICPC形成凝膠的時間，約為2 563~2 600 s。此外，隨著黃原膠含量的增加，ICPC觸變環面積增加，但形成的網絡結構在高剪切狀態下并不穩定。

Abstract:

The influence of additives on the rheological properties of injectable calcium phosphate cement (ICPC) was investigated with an advanced expansion system rheometer. During the measurement of steady rheological properties, the viscosity, shear stress, and thixotropy were detected. During dynamic oscillation testing, the viscoelastic response of the ICPC under forced oscillation and the internal structure were unvailled. The results indicated that the ICPC showed both plastic and thixotropic behavior with little effect by additives. The introduction of these water soluble polymers improved the viscosity and thixotropy of the ICPC, which are conducive to the stability of the whole system. These additives improve the recoverability and stability of the ICPC network after being sheared, in which xanthan gum and chitosan were the most obvious. On this basis, the time to form a gel was assessed to be in the range of 2 563~2 600 s for xanthan gum�睮CPC system. In addition, with the increasing of xanthan gum contents, the thixotropic loop area of ICPC enlarged, but the formation of network structure was not stable under high shear condition.