文章信息/Info

Title:

The Development of Construction of Small Diameter Vascular Grafts in Vivo

作者:

王淑芳; 鄭文婷; 孔德領(lǐng)

(南開大學(xué)生命科學(xué)學(xué)院 藥物化學(xué)生物學(xué)國家重點(diǎn)實(shí)驗(yàn)室，天津 300071)

Author(s):

WANG Shufang;  ZHENG Wenting;  KONG Deling

(State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China)

關(guān)鍵詞:

人工血管; 組織工程; 支架制備; 干細(xì)胞捕捉; 內(nèi)皮化; 平滑肌再生; 細(xì)胞外微環(huán)境

DOI:

10.7502/j.issn.1674-3962.2012.09.02

文獻(xiàn)標(biāo)志碼:

A

摘要:

小口徑血管在臨床上有很大需求，但小口徑血管再狹窄率很高。體內(nèi)組織工程是改善小口徑血管功能、實(shí)現(xiàn)血管再生的有效手段。介紹了小口徑人工血管的國內(nèi)外研究發(fā)展動(dòng)態(tài)，詳述了作者實(shí)驗(yàn)室在構(gòu)建小口徑人工血管方面的設(shè)計(jì)思路和研究所取得的主要進(jìn)展。研究包括支架材料結(jié)構(gòu)設(shè)計(jì)與制備技術(shù)，支架材料表面功能化修飾，內(nèi)皮祖細(xì)胞捕捉，血管平滑肌再生，抗凝血和促內(nèi)皮細(xì)胞黏附，血管再生微環(huán)境的構(gòu)建等。最后對(duì)小口徑人工血管研究尚需解決的科學(xué)問題和研究方向進(jìn)行了討論。��

Abstract:

Although there is a growing demand of small diameter vascular grafts for cardiovascular disease, the incidence rate of restenosis caused by vascular grafts remains high. An effective approach to improve the function of small�瞕iameter vascular grafts and realize the blood vessel regeneration would be to induce a healing response in vivo for tissue engineering. In this article, we summarize the recent research developments on small�瞕iameter vascular grafts, and highlight the main designing ideas and research outcomes in our laboratory. The work includes structural design and fabrication of porous scaffolds, anti�瞔lotting modification, functionalization for endothelial progenitor cells (EPCs) capture, creation of micro�瞖nvironment for vascular smooth muscle regeneration and angiogenesis. Some directions and problems on future research in these areas are also discussed.