文章信息/Info

Title:

Research Progress on Biodegradable Metallic Endovascular Stents

作者:

吳遠浩; 周曉晨; 李楠; 鄭玉峰

（1.北京大學前沿交叉學科研究院 生物醫用材料與組織工程中心，北京 100871）��
（2.北京大學工學院 材料科學與工程系，北京100871）

Author(s):

WU Yuanhao;  ZHOU Xiaochen;  LI Nan;  ZHENG Yufeng

(1 Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China)��
(2 Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China)

關鍵詞:

鎂合金; 鐵; 血管支架; 生物降解; 有限元分析

DOI:

10.7502/j.issn.1674-3962.2012.09.04

文獻標志碼:

A

摘要:

隨著心血管疾病治療技術的發展，各種金屬血管支架作為治療心血管疾病的最有效器械之一，已經越來越受到人們的關注。重點介紹了目前研究最廣泛的2類可降解金屬血管支架材料：鎂基合金和鐵基合金。總結了這2類血管支架用可降解金屬材料的研究進展，血管支架器械的動物試驗和臨床試驗研究成果。歸納了可降解金屬血管支架的有限元結構設計、應力分析、體內體外降解性能和生物相容性等需要重點考慮的屬性。指出了可降解金屬血管支架目前存在的不足，并對可降解金屬血管支架未來的研究方向和發展前景進行了展望。��

Abstract:

With the development of new technology to treat cardiovascular disease (CVD), cardiovascular stents have drawn more and more attention as one of the most effective device in the treatment of CVD. In this paper, we mainly focused on two types of biodegradable metallic vascular stents which are mostly investigated nowadays,namely magnesium alloy stents and iron based alloy stents. We summarized the research progresses on these biodegradable metallic alloys from the viewpoint of materials science in the present days and the animal experiments, clinic trail results of their stents as well. We overviewed about the finite element design, stress analysis, mechanical property, degradation performance, biocompatibility of the biodegradable metallic stents. Finally, we pointed out the deficiency of current biodegradable metallic stent and their future research direction.��