文章信息/Info

Title:

Bone Regeneration Mechanism of Advanced Biomaterials for Hard Tissue Repair

作者:

鄒學農; 陳大福; 田偉; 張西正; 吳剛; 董華; 周永勝; 周光前

（1.中山大學附屬第一醫院骨科研究所，廣東 廣州 510080)��
(2.北京積水潭醫院創傷骨科研究所，北京 100035)��
(3.中國人民解放軍軍事醫學科學院衛生裝備研究所，天津 300161)��
(4.華南理工大學國家人體組織功能重建工程技術研究中心，廣東 廣州 510006)��

Author(s):

 ZOU Xuenong ; CHEN Dafu;  TIAN Wei;  ZHANG Xizheng;  WU Gang;  DONG Hua;  ZHOU Yongsheng;  ZHOU Guangqian

 1. Orthopaedic Research Institute, First Affiliated Hospital of Sun Yat�瞫en University, Guangzhou 510080, China）��

關鍵詞:

硬組織修復材料; 骨再生; 宿主防御; 宿主微環境; 表觀遺傳學; 基因調控

DOI:

10.7502/j.issn.1674-3962.2012.09.06

文獻標志碼:

A

摘要:

傳統硬組織修復材料由于在組成及結構上與人體骨組織存在較大差異，植入體內后的骨組織修復過程基本上是一種被動的“充填”過程，且材料的降解速度與新骨形成速度不匹配，難以達到真正的“生物性融合”，嚴重制約了該類材料在骨科臨床的推廣應用。因此，設計與制備具有“主動修復功能”和“可調控生物響應特性”的第3代新型硬組織修復材料已成為當前骨科臨床的新需求和未來的發展方向。介紹了硬組織修復材料的骨再生機理研究方法，綜述了硬組織修復材料與宿主防御和骨再生及宿主微環境對材料與宿主細胞相互作用的研究現狀。指出硬組織修復材料植入體內后所發生的序列事件可能通過表觀遺傳修飾使得基因表達受材料本身和宿主微環境等因素的調控，提出新型硬組織修復材料研究中存在的問題和發展趨勢。��

Abstract:

Traditional biomaterials for hard tissue repair in composition and structure are hugely different with human bone tissue. The repairing process of these materials is basically a passive “filling” process when implanted in the body. Because new bone formation and material degradation rate do not match well enough, it is difficult to achieve the real “biological fusion”, and this restricted the use of materials in orthopaedic clinical application. Therefore, design and preparation of advanced third generation biomaterials for hard tissue repair with “active repair function” and “controlled biological response characteristics” has become the new demand of orthopaedic clinical application and future research direction. This paper introduced main research methods for bone regeneration mechanisms of advanced biomaterials for hard tissue repair, and it also summarized the current research results of interactions between these biomaterials and host cells in host microenvironment, and interactions between the biomaterials and host defense responses in the process of bone regeneration.