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[1]黃千里,劉淵聲,馮慶玲. 珍珠層，一種具有潛力的天然骨修復材料[J].中國材料進展,2013,(10):023-31.[doi:10.7502/j.issn.1674-3962.2013.10.03]
　Qianli Huang,Yuansheng Liu,Qingling Feng. Nacre, a potential natural biomaterial for bone regeneration[J].MATERIALS CHINA,2013,(10):023-31.[doi:10.7502/j.issn.1674-3962.2013.10.03]
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 珍珠層，一種具有潛力的天然骨修復材料()
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中國材料進展[ISSN:1674-3962/CN:61-1473/TG]

卷:
期數:
2013年第10期
頁碼:
023-31
欄目:
特約研究論文
出版日期:
2013-10-31

文章信息/Info

Title:
 Nacre, a potential natural biomaterial for bone regeneration
作者:
 黃千里; 劉淵聲; 馮慶玲
 （清華大學材料學院先進材料教育部重點實驗室，北京 100084）
Author(s):
 Qianli Huang;  Yuansheng Liu;  Qingling Feng
 

（Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China）

關鍵詞:
 ; 珍珠層; 成骨特性; 體外; 體內
DOI:
10.7502/j.issn.1674-3962.2013.10.03
文獻標志碼:
A
摘要:
 由于骨質疏松、骨折、骨腫瘤等原因導致的骨缺損困擾著世界上成千上萬的人。近年來，關于骨缺損修復材料的研究已得到了國內外科研工作者的廣泛關注。珍珠層是組成許多軟體動物貝殼的結構單元之一。與骨組織類似，珍珠層也是一種由無機相礦物與有機基質組成的復合材料。雖然珍珠層與骨組織具有非同源性，但是，其部分的形成機理可能具有類似性。本文綜述了近年來國內外關于珍珠層研究的大量體外與體內實驗結果，這些實驗結果表明了珍珠層具有良好的生物相容性與成骨特性，有可能成為一種具有潛力的天然骨修復材料。珍珠層的成骨特性很有可能來源于其有機基質中的未知信號因子。同時，本文也提出了珍珠層用作天然骨修復材料在今后研究中的機遇與挑戰。
Abstract:
 Bone loss due to osteoporosis, bone fracture, bone tumor and trauma affects hundreds of millions of people all over the world. Materials for the purpose of repairing bone defects have received extensive attention from many researchers at home and abroad in recent years. Nacre, which forms the inner layer of many mollusk shells, is also a composite of inorganic minerals and organic matrix similar to the structure of bone. Although nacre and bone are not homologous, parts of the complex machinery that directs their formation might be. Plenty of evidences of experiments about nacre both in vivo and in vitro in recent years are reviewed in this paper. The results present that nacre with its biocompatibility and osteogenic property might be a potential natural biomaterial for bone regeneration. The osteogenic property of nacre might probably be profited from some unknown signaling molecules within the organic matrix of nacre. Future perspectives and challenges for nacre to be applied as a natural biomaterial for bone regeneration are also proposed in this review.

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備注/Memo

備注/Memo:
 

基金項目：國家自然科學基金(51072090)

作者簡介：黃千里（1990—），男，在讀博士生。主要研究方向：生物醫用材料。

通信聯系人：馮慶玲，女，教授，博士生導師， E-mail: biomater@mail.tsinghua.edu.cn

更新日期/Last Update: 2013-10-11
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