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[1]彭耿,王靖,劉昌勝.葡聚糖/殼聚糖水凝膠的制備及其作為生長因子載體的研究[J].中國材料進展,2013,(10):599-604.[doi:10.7502/j.issn.1674-3962.2013.10.04]
 PENG Geng,WANG Jing,LIU Changsheng.Preparation of Dextran/Chitosan hydrogel and application on the carriers of growth factor PENG Geng, WANG Jing, LIU Changsheng[J].MATERIALS CHINA,2013,(10):599-604.[doi:10.7502/j.issn.1674-3962.2013.10.04]
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葡聚糖/殼聚糖水凝膠的制備及其作為生長因子載體的研究()
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中國材料進展[ISSN:1674-3962/CN:61-1473/TG]

卷:
期數(shù):
2013年第10期
頁碼:
599-604
欄目:
特約研究論文
出版日期:
2013-10-31

文章信息/Info

Title:
Preparation of Dextran/Chitosan hydrogel and application on the carriers of growth factor PENG Geng, WANG Jing, LIU Changsheng
作者:
彭耿王靖劉昌勝
(華東理工大學,教育部生物醫(yī)用材料工程研究中心,上海 200237)
Author(s):
 PENG Geng WANG Jing LIU Changsheng
(East China University of Science and Technology, Engineering Research Center for Biomedical Materials of Ministry of Education, Shanghai 200237, China)
關鍵詞:
水凝膠組織再生葡聚糖殼聚糖生長因子
分類號:
R318.08
DOI:
10.7502/j.issn.1674-3962.2013.10.04
文獻標志碼:
A
摘要:
本文合成并表征了砜基葡聚糖(Dex-VS)和巰基化殼聚糖(CS-SH),利用邁克爾加成反應,以巰基化殼聚糖為大分子交聯(lián)劑,制備了葡聚糖/殼聚糖(Dex /CS)水凝膠,采用掃描電鏡(SEM)考察了凝膠支架的形貌,并研究了降解行為。研究發(fā)現(xiàn),水凝膠的降解時間可由前驅物濃度以及砜基取代度來調控。細胞毒性研究表明該水凝膠具有良好的生物相容性。在此基礎上,將其負載骨誘導生長因子人重組骨形態(tài)發(fā)生蛋白-2(rhBMP-2)后植入老鼠肌袋內,評價動物體內異位成骨的情況。通過新生異位骨的成骨量以及組織學評價結果表明,負載rhBMP-2的凝膠支架具有良好的異位成骨效果。本研究表明此類凝膠有望作為一種新型的可注射生長因子載體用于組織修復。
Abstract:
Dextran vinyl sulfone (Dex-VS) and mercapto chitosan (CS-SH) derivates were synthesized and characterized in the study. In addition, CS-SH was selected as a kind of macromolecular crosslinking agent taking advantage of the Michael addition between 朧S and 朣H groups, thus generated dextran-based hydrogel network. Morphology of the hydrogel scaffold was inspected through scanning electron microscope (SEM). Various degradation behaviors under different conditions were investigated. The duration time can be regulated via both concentration of dextran precursors and degree of substitutions. Cellular biocompatibility of the hydrogel was confirmed through MTT assay. Based on the above results, the inductive growth factor, rhBMP-2, was loaded into the scaffold and implanted into mouse thigh muscles to investigate ectopic bone formation. Mass of neo-bone was notable observed compared to control group, as well as the histological evaluations. Consequently, such kind of hydrogel might give promising application in tissue regeneration and delivery of growth factors.

參考文獻/References:

References
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備注/Memo

備注/Memo:
收稿日期: 基金項目:科技部973計劃項目(2012CB933600)
第一作者: 彭耿 ,男,1987年生,碩士生通信作者:劉昌勝 ,男,1967年生,教授,博士生導師
更新日期/Last Update: 2013-10-11
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