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[1]郭大偉,朱玲英,顧寧.磁性納米顆粒作為基因遞送載體的研究進展[J].中國材料進展,2013,(10):605-610.[doi:10.7502/j.issn.1674-3962.2013.10.05]
 Guo Dawei,Zhu lingying,Gu Ning.Progress on magnetic nanoparticles as a gene delivery carrier[J].MATERIALS CHINA,2013,(10):605-610.[doi:10.7502/j.issn.1674-3962.2013.10.05]
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磁性納米顆粒作為基因遞送載體的研究進展()
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中國材料進展[ISSN:1674-3962/CN:61-1473/TG]

卷:
期數:
2013年第10期
頁碼:
605-610
欄目:
特約研究論文
出版日期:
2013-10-31

文章信息/Info

Title:
Progress on magnetic nanoparticles as a gene delivery carrier
作者:
郭大偉朱玲英顧寧
(東南大學 生物科學與醫學工程學院,江蘇 南京 210096)
Author(s):
Guo Dawei Zhu lingying Gu Ning
(School of Biology and Medicine Engineering, Southeast University, Nanjing 210096, Jiangsu)
關鍵詞:
磁性納米顆粒基因遞送磁轉染載體
DOI:
10.7502/j.issn.1674-3962.2013.10.05
摘要:
基因遞送是實現基因治療的關鍵,基因的有效遞送有賴于發展有效的、安全的遞送載體。理想的基因遞送載體應具備遞送效率高、細胞毒性低、對正常細胞生理影響小以及易于使用和重復等特性。納米材料獨特的理化性質使其在藥物和基因遞送領域具有潛在的應用。磁性納米顆粒兼具納米效應和超順磁性,是一種非常有應用前景的載體材料。本文簡要介紹了納米顆粒的類型、粒徑、表面特性和外加磁場等因素對磁性納米顆;蜻f送的影響,并就磁性納米顆粒作為基因遞送載體的應用和面臨的主要挑戰進行了總結和展望。
Abstract:
Effective gene delivery is critical for gene therapy, and depends on the development of effective and safe delivery carrier. Ideal carrier of gene delivery should possess plenty of properties, including high delivery efficiency, low cytotoxicity, less effect on physiological effect of normal cells, and ease of use and duplication. Nanomaterials have potential applications in the field of drug and gene delivery due to unique physical and chemical properties. Magnetic nanoparticles with nano-effect and superparamagnetic properties are very promising delivery carrier. We briefed the key factors affecting the gene delivery of MNPs, including the types, size and surface properties of nanoparticles and external magnetic field. The current applications and challenges of MNPs in gene delivery was summarized and discussed.

參考文獻/References:

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備注/Memo

備注/Memo:
基金項目:國家自然科學基金資助項目(59493300);教育部博士點基金資助項目(9800462)_____________________ 收稿日期: 2000-03-11;修訂日期:2000-03-06
更新日期/Last Update: 2013-10-11
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