參考文獻 References [1] Ortiz R, Melguizo C, Prados J, et al. New gene therapy strategies for cancer treatment: a review of recent patents [J]. Recent Pat Anticancer Drug Discov. 2012,7 (3): 297-312. [2] Martinez T, Wright N, Lopez-Fraga M, et al. Silencing human genetic diseases with oligonucleotide-based therapies [J]. Hum Genet. 2013, 132 (5): 481-493. [3] Evans C H, Ghivizzani S C, Robbins P D. Arthritis gene therapy and its tortuous path into the clinic [J]. Transl Res. 2013,161 (4): 205-216. [4] Southerland K W, Frazier S B, Bowles D E, et al. Gene therapy for the prevention of vein graft disease [J]. Transl Res. 2013, 161 (4): 321-338. [5] Thomas C E, Ehrhardt A, Kay M A. Progress and problems with the use of viral vectors for gene therapy [J]. Nat Rev Genet. 2003 (4): 346-358. [6] Wang W, Li W, Ma N, et al. Non-viral gene delivery methods [J]. Curr Pharm Biotechnol. 2013,14 (1): 46-60. [7] Li S D, Huang L. Gene therapy progress and prospects: non-viral gene therapy by systemic delivery [J]. Gene Ther. 2006,13 (18): 1313-1319. [8] Mellott A J, Forrest M L, Detamore M S. Physical non-viral gene delivery methods for tissue engineering [J]. Ann Biomed Eng. 2013, 41 (3): 446-468. [9] De Laporte L, Cruz Rea J, Shea L D. Design of modular non-viral gene therapy vectors [J]. Biomaterials. 2006, 27 (7): 947-954. [10] Jin S, Ye K. Nanoparticle-mediated drug delivery and gene therapy [J]. Biotechnol Prog. 2007, 23 (1): 32-41. [11] Vijayanathan V, Thomas T, Thomas T J. DNA nanoparticles and development of DNA delivery vehicles for gene therapy [J]. Biochemistry. 2002, 41 (48): 14085-14094. [12] Katragadda C S, Choudhury P K, Murthy P N. Nanoparticles as non-viral gene delivery vectors [J]. Indian J Pharm Educ Res. 2010, 44 (2): 109-120. [13] Xiang J J, Nie X M, Tang J Q, et al. In vitro gene transfection by magnetic iron oxide nanoparticles and magnetic field increases transfection efficiency [J]. Zhonghua Zhong Liu Za Zhi. 2004, 26 (2): 71-74. [14] Fouriki A, Farrow N, Clements M A, et al. Evaluation of the magnetic field requirements for nanomagnetic gene transfection [J]. Nano Rev. 2010, (1): 5167. [15] Delyagina E, Li W, Ma N, et al. Magnetic targeting strategies in gene delivery. Nanomedicine [J]. 2011, 6 (9): 1593-1604. [16] Schwerdt J I, Goya G F, Calatayud M P, et al. Magnetic field-assisted gene delivery: achievements and therapeutic potential [J]. Curr Gene Ther. 2012, 12 (2): 116-126. [17] Makarewicza M, PodsiadAlyb M, BaAlandaa M. Magnetic investigation of carbon coated Co-, Ni- and Fe-nanoparticles [J]. Acta Phys Pol A. 2009, 115 (2): 568-571. [18] Tomitaka A, Kobayashi H, Yamada T, et al. Magnetization and self-heating temperature of NiFe2O4 nanoparticles measured by applying ac magnetic field [J]. J Phys: Conf Ser. 2010, 200 (12): 122010. [19] Cho W S, Duffin R, Poland C A, et al. Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs [J]. Nanotoxicology. 2012, 6 (1): 22-35. [20] George S, Xia T, Rallo R, et al. Use of a high-throughput screening approach coupled with in vivo zebrafish embryo screening to develop hazard ranking for engineered nanomaterials [J]. ACS Nano. 2011, 5 (3): 1805-1817. [21] Akbarzadeh A, Samiei M, Davaran S. Magnetic nanoparticles: preparation, physical properties, and applications in biomedicine [J]. Nanoscale Res Lett. 2012, 7 (1): 144. [22] Kami D, Takeda S, Itakura Y, et al. Application of magnetic nanoparticles to gene delivery [J]. Int J Mol Sci. 2011, 12 (6): 3705-3722. [23] Chen Z, Yin J J, Zhou Y T, et al. Dual enzyme-like activities of iron oxide nanoparticles and their implication for diminishing cytotoxicity [J]. ACS Nano. 2012, 6 (5): 4001-4012. [24] Morishita N, Nakagami H, Morishita R, et al. Magnetic nanoparticles with surface modification enhanced gene delivery of HVJ-E vector [J]. Biochem Biophys Res Commun. 2005, 334 (4): 1121-1126. [25] Pan B, Cui D, Sheng Y, et al. Dendrimer-modified magnetic nanoparticles enhance efficiency of gene delivery system [J]. Cancer Res. 2007, 67 (17): 8156-8163. [26] Kievit F M, Veiseh O, Bhattarai N, et al. PEI-PEG-Chitosan Copolymer Coated Iron Oxide Nanoparticles for Safe Gene Delivery: synthesis, complexation, and transfection [J]. Adv Funct Mater. 2009, 19 (14): 2244-2251. [27] Lungwitz U, Breunig M, Blunk T, et al. Polyethylenimine-based non-viral gene delivery systems [J]. Eur J Pharm Biopharm. 2005, 60 (2): 247-266. [28] Lu Yanming (盧艷敏), Cui Haixing (崔海信), Cui Jinhui (崔金輝), 等. 磁性納米顆粒作為基因轉染載體的研究 [J]. Biotechnology Bulletin (生物技術通報). 2012, (8): 199-204. [29] Wang B, Zhang S, Cui S, et al. Chitosan enhanced gene delivery of cationic liposome via non-covalent conjugation [J]. Biotechnol Lett. 2012, 34 (1): 19-28. [30] Kuang Y, Yuan T, Zhang Z, et al. Application of ferriferous oxide modified by chitosan in gene delivery [J]. J Drug Deliv. 2012, (2012): 920764. [31] Chen Chaoting (陳朝婷), Gao Feng (高峰), 陸平 (Lu Ping), 等. 磁性殼聚糖納米介導 eNOS 基因轉染受損平滑肌細胞初探 [J]. Journal of Southeast University (Medical Science Edition) (東南大學學報(醫學版)). 2011, 30 (6): 827-831. [32] Zhou Y, Tang Z, Shi C, et al. Polyethylenimine functionalized magnetic nanoparticles as a potential non-viral vector for gene delivery [J]. J Mater Sci Mater Med. 2012, 23 (11): 2697-2708. [33] Prijic S, Prosen L, Cemazar M, et al. Surface modified magnetic nanoparticles for immuno-gene therapy of murine mammary adenocarcinoma [J]. Biomaterials. 2012, 33 (17): 4379-4391. [34] Zhang Z B, Song L N, Dong J L, et al. A Promising Combo Gene Delivery System Developed from (3-Aminopropyl)triethoxysilane-Modified Iron Oxide Nanoparticles and Cationic Polymers [J]. J Nnanopart Res. 2013, 15 (4): 1-11. [35] Chouly C, Pouliquen D, Lucet I, et al. Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution [J]. J Microencapsul. 1996, 13 (3): 245-255. [36] Yan K, Li P, Zhu H, et al. Recent advances in multifunctional magnetic nanoparticles and applications to biomedical diagnosis and treatment [J]. RSC Adv. 2013, 3 (27): 10598-10618. [37] Ruiz A, Salas G, Calero M, et al. Short-chain PEG molecules strongly bound to magnetic nanoparticle for MRI long circulating agents [J]. Acta Biomater. 2013, 9 (5): 6421-6430. [38] Huang J, Bu L, Xie J, et al. Effects of nanoparticle size on cellular uptake and liver MRI with polyvinylpyrrolidone-coated iron oxide nanoparticles [J]. ACS Nano. 2010, 4 (12): 7151-7160. [39] Kamei K, Mukai Y, Kojima H, et al. Direct cell entry of gold/iron-oxide magnetic nanoparticles in adenovirus mediated gene delivery [J]. Biomaterials. 2009, 30 (9): 1809-1814. [40] Dobson J. Gene therapy progress and prospects: magnetic nanoparticle-based gene delivery [J]. Gene Ther. 2006, 13 (4): 283-287. [41] Kuang Y, Yuan T, Zhang Z, et al. Application of ferriferous oxide modified by chitosan in gene delivery [J]. J Drug Deliv. 2012, (2012): 920764. [42] Zhang H, Lee M Y, Hogg M G, et al. Gene delivery in three-dimensional cell cultures by superparamagnetic nanoparticles [J]. ACS Nano. 2010, 4 (8): 4733-4743. [43] McBain S C, Griesenbach U, Xenariou S, et al. Magnetic nanoparticles as gene delivery agents: enhanced transfection in the presence of oscillating magnet arrays [J]. Nanotechnology. 2008, 19 (40): 405102. [44] Kamau S W, Hassa P O, Steitz B, et al. Enhancement of the efficiency of non-viral gene delivery by application of pulsed magnetic field [J]. Nucleic Acids Res. 2006, 34 (5): e40. [45] Jenkins S I, Pickard M R, Granger N, et al. Magnetic nanoparticle-mediated gene transfer to oligodendrocyte precursor cell transplant populations is enhanced by magnetofection strategies [J]. ACS Nano. 2011, 5 (8): 6527-6538. [46] Plank C, Zelphati O, Mykhaylyk O. Magnetically enhanced nucleic acid delivery. Ten years of magnetofection-progress and prospects [J]. Adv Drug Deliv Rev. 2011, 63 (14-15): 1300-1331. [47] Adams C F, Pickard M R, Chari D M. Magnetic nanoparticle mediated transfection of neural stem cell suspension cultures is enhanced by applied oscillating magnetic fields [J]. Nanomedicine. 2013, 9 (6): 737-741. [48] Hu S H, Hsieh T Y, Chiang C S, et al. Surfactant-Free, Lipo-Polymersomes Stabilized by Iron Oxide Nanoparticles/Polymer Interlayer for Synergistically Targeted and Magnetically Guided Gene Delivery [J]. Adv Healthc Mater. 2013 doi: 10.1002/adhm.201300122. [49] Kong S D, Lee J, Ramachandran S, et al. Magnetic targeting of nanoparticles across the intact blood-brain barrier [J]. J Control Release. 2012, 164 (1): 49-57. [50] Kuang Y, An S, Guo Y, et al. T7 peptide-functionalized nanoparticles utilizing RNA interference for glioma dual targeting [J]. Int J Pharm. 2013, 454 (1): 11-20. [51] Wang X, Chen B, Yang X, et al. Functionalized superparamagnetic nanoparticles for highly-efficient gene delivery [J]. J Nanosci Nanotechnol. 2013, 13 (2): 746-750.