文章信息/Info

Title:

Hemocompatibility of Commodity Polymers Modified with Chemical and Biological Method

作者:

石強; 欒世方; 金晶; 石恒沖; 殷敬華; 李勇剛

中國科學院長春應用化學研究所 高分子物理與化學國家重要實驗室， 長春，130022
威高集團有限公司，威海，264209

Author(s):

SHI Qiang; LUAN Shifang; JIN Jing; SHI Hengchong;  YIN Jinghua*

?State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

關鍵詞:

通用高分子; 化學和生物改性; 血液相容性

DOI:

10.7502/j.issn.1674-3962.2014.04.03

文獻標志碼:

A

摘要:

功能化與高性能化的通用高分子材料在醫用耗材及器械領域有著廣泛的應用。作為重要的醫用材料之一，血液相容性是首先需要解決的關鍵科學問題。通用高分子的血液相容性可通過化學和生物修飾來實現。采用的方法大體分為本體改性和表面改性。本體改性主要通過反應接枝和反應共混實現；而表面改性則主要通過在材料表面（1）制備親水性聚合物刷或親水層，(2) 固定生物活性分子和（3）形成生物仿生膜來實現。目前，生物材料的血液相容性研究主要集中在血漿蛋白吸附、血小板黏附和紅細胞溶血三個方面。本文結合本課題組近期在生物醫用材料領域的研究成果，簡要介紹了國內外近年來通用高分子材料的化學和生物改性及其血液相容性研究進展。

Abstract:

Commodity polymers with high functionality and performance are widely applied in the field of biomedical supplies and equipment. As one of most important biomaterials, hemocompatibility is a key challenge. The hemocompatibility of commodity polymers can be improved with chemical and biological method, including bulk and surface modification in general. Bulk modification was obtained by melt grafting and blending, while surface modification could be achieved through (i) surface passivation with hydrophilic layers, (ii) immobilization of bioactive molecules and (iii) formation of biomimetic membrane. The investigation of hemocompatibility was mainly concentrated on plasma protein adsorption, platelet adhesion and hemolysis of red blood cell. This report presents an overview on hemocompatibility of modified commodity polymers, with focus on the progress achieved by our research group in Changchun Institute of Applied Chemistry in recent years.