文章信息/Info

Title:

Construction of Drug-Loaded Electrospun Organic/Inorganic Hybrid Nanofibers for Biomedical Applications

作者:

 王 哲;  史向陽

東華大學化學化工與生物工程學院，上海，201620

Author(s):

WANG Zhe;  SHI Xiangyang

College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China

關(guān)鍵詞:

靜電紡; 雜化納米纖維; 藥物載體; 生物醫(yī)學應用

DOI:

10.7502/j.issn.1674-3962.2014.11.03

文獻標志碼:

A

摘要:

納米纖維具有諸如極大的比表面積、可控的多孔二級結(jié)構(gòu)等一系列優(yōu)良特性，使其在環(huán)境保護、能源利用、催化劑、藥物載體、組織工程支架材料等領(lǐng)域得到了廣泛應用。通過靜電紡技術(shù)制備的納米纖維主要有有機納米纖維、無機納米纖維、以及無機/有機雜化納米纖維三類。本文結(jié)合課題組之前的研究成果積累，綜述了各種不同的靜電紡有機/無機雜化納米纖維載藥體系的構(gòu)建及其生物醫(yī)學應用。著重介紹了如何將藥物負載在無機納米顆粒（埃洛石、鋰皂石、羥基磷灰石、介孔二氧化硅等）的表面或內(nèi)部并進而和高分子混紡形成雙載體的過程和相關(guān)藥物緩釋機理，并探討了雜化納米纖維載藥體系的生物醫(yī)學應用，尤其是在抗菌和抗腫瘤方面的治療應用。文章最后對該領(lǐng)域的相關(guān)研究作了展望。

Abstract:

The distinctive features of nanofibers (such as huge surface area to volume ratio, controllable porous secondary structure, etc) enable them to be widely used in the fields of environmental protection, energy, catalysts, drug delivery, and tissue engineering scaffolds. Nanofibers prepared by electrospinning technology mainly include organic nanofibers, inorganic nanofibers, and inorganic/organic hybrid nanofibers. In this review, based on our previous work associated with electrospun hybrid nanofiber systems, the construction of various drug-loaded electrospun organic/inorganic hybrid nanofibers for biomedical applications has been reviewed. In particular, this review mainly introduces the loading of drug molecules onto or within various inorganic nanoparticles (e. g. , halloysite nanotubes, laponite nanodisks, nanohydroxyapatite, mesoporous silica, etc.) for subsequent electrospinning with polymers to form electrospun hybrid nanofiber-based double drug carrier systems, and the associated mechanisms related to the sustained release of the encapsulated drug molecules. The biomedical applications of the drug-loaded hybrid electrospun nanofibers, especially in antibacterial and antitumor therapy applications have been also reviewed. The review ends with a brief outlook of some of the future aspects of this area of research.