文章信息/Info

Title:

 Advance in Biodegradable Stent

作者:

 皇甫強1;  袁思波1;  韓建業1;  于振濤2;  余森2; 張亞峰2;  麻西群2; 劉春潮2;  程軍2

1.西安九洲生物材料有限公司，陜西 西安
2.西北有色金屬研究院，陜西 西安

Author(s):

 HUANGFU Qiang1; YUAN Sibo1; HAN Jianye1; YU Zhentao2; YU Sen2; ZHANG Yafeng2; MA Xiqun2; LIU Chunchao2; CHENG Jun2

1.Xi’an Continental Biomaterials Co.,Ltd., Xi’an
2.Northwest Institute for Nonferrous Metal Research, Xi’an

關鍵詞:

生物可降解; 鎂合金; 純鐵; 聚乳酸; 鋅合金; 支架

DOI:

10.7502/j.issn.1674-3962.2015.05.12

文獻標志碼:

A

摘要:

盡管目前介入用血管支架各類藥物涂層技術較從前已經獲得長足的進步，涂層支架的臨床使用數量也遠遠超過了裸支架，但遠期療效仍有待繼續驗證。無論何種藥物涂層支架，當其被植入生物體內一段時間后，表面攜帶的功能藥物涂層都會被生物體逐漸吸收而最終露出裸支架，因此并不能徹底改善現有支架所存在的諸多問題。因此，生物可降解支架應運而生，由于其具有獨特的可降解性，隨著植入時間的延長而逐漸在生物體內被完全降解，最終代謝出體外，同時，血管自有的部分原始功能也得到一定恢復，如同從未被植入過支架一般。重點論述了國內外鎂合金、純鐵、聚乳酸、鋅合金幾種不同材質的生物可降解血管支架研究現狀，并分析了各材質可降解支架現存的主要問題，希望對介入用生物可降解血管支架的發展和應用起到一定的積極作用。

Abstract:

Although various types of stent drug coating technologies have made great progress, and the quantity of drug coating stents utilization is also more than that of non-drug coating stents in clinical application, however the long-term efficacy remains being observed. Regardless of what drug coating stent, when it was implanted in the body for a long time, the drug coating will be gradually absorbed and the material of stent is exposed, so the problems of the non-drug coating stents can not be completely solved. Biodegradable stent is different from other stents, it can be degraded when implanted in the human body. After a period of time, it was degraded completely and is excreted, as if not being implanted in general. This paper not only described the different biodegradable materials stents, including magnesium alloy, pure iron, polylactide and zinc alloy stent,but also analyzed the problems of different biodegradable stents, wishing to play a positive role in the development and application of biodegradable stent.