文章信息/Info

Title:

Biodegradation Behavior of Silk Fibroin Materials

作者:

李明忠1; 張 劍2; 邱玉華3; 盧神州1

1. 蘇州大學現代絲綢國家工程實驗室，江蘇 蘇州 215021

2. 上海交通大學醫學院附屬瑞金醫院燒傷科，上海 200025

3. 蘇州大學醫學部免疫學系，江蘇 蘇州 215021

Author(s):

LI Mingzhong1; ZHANG Jian2; QIU Yuhua3; LU Shenzhou1

1. National Engineering Laboratory for Modern Silk, Soochow University, Suzhou 215123, China

2. Department of Burn Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University，Shanghai 200025, China

3. Department of Immunology, Medical College, Soochow University, Suzhou 215123, China

關鍵詞:

蠶絲; 絲素; 生物降解; 蛋白酶

DOI:

10.7502/j.issn.1674-3962.2015.07.11

文獻標志碼:

A

摘要:

蠶絲絲素材料植入體內后的降解可直接造成其形態和結構變化，力學性能和質量下降。降解產物與組織反應或全身反應的程度密切相關。用于組織工程和再生醫學的絲素支架材料的生物降解速率應與組織再生速率相匹配，用于藥物控制釋放系統的絲素載體的生物降解速率應與生物活性物質的釋放需要相適應。本文概述了近年對絲素材料的生物降解問題的研究現狀。介紹了通過體外、體內實驗所觀察到的絲素材料的生物降解行為，包括天然絲素纖維以及再生絲素纖維、多孔支架、薄膜等。討論了材料的形態和結構等對生物降解行為的影響。總結了未來需要進一步研究的問題。指出蠶絲絲素作為一種蛋白質可被多種蛋白酶催化水解；天然絲素纖維比再生絲素材料的生物降解速率慢；絲素的分子構象、結晶度、交聯程度、材料的形態等對絲素的降解速率有明顯影響。建立預測絲素材料的生物降解程度與其功能變化以及與機體應答關系的研究模型和技術，有效調控其生物降解速率，是未來的研究方向。

Abstract:

Degradation behavior of silk fibroin materials after in vivo implantation affects the morphological, structural and mechanical properties and gives rise to the mass loss of materials, and degradation products are closely related to the host tissue and body responses. The degradation rate of silk fibroin scaffolds and drug carriers should mirror the rate of tissue regeneration or be adequate for the controlled release of bioactive molecules. Here, this paper summarizes the degradation behaviors of silk-based materials over the last few years through introducing in vitro and in vivo degradation properties of natural silk fibroin fibers and regenerated silk fibroin materials including regenerated silk fibroin fibers, films and porous scaffolds, discussing the influences of morphological and structural features on degradation rate of silk fibroin materials, and further highlights the potential issues. The results obtained from current state researches indicate that silk fibroin can be hydrolyzed by various proteinases in vitro and in vivo. The regenerated silk fibroin materials show a rapid degradation rate compared to natural silk fibroin fibers. Furthermore, the molecular conformation, crystallinity, crosslinking degree and morphological features significantly influence the degradation rate of regenerated silk fibroin materials. It will be the aim of future research that to develop the models and technology can predict the biodegradation degree and functional alteration of biomaterials as well as the host body responses to the biomaterials, effectively controlling the degradation rate of biomaterials.