文章信息/Info

Title:

Progress in tough and responsive hydrogels

作者:

高國榮 杜高來 孫元娜 付俊

中國科學院寧波材料技術與工程研究所

Author(s):

GAO Guorong;  DU Gaolai;  SUN Yuanna;  FU Jun

Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences

關鍵詞:

水凝膠; 強度; 韌性; 響應性

DOI:

10.7502/j.issn.1674-3962.2015.07.12

文獻標志碼:

A

摘要:

高分子水凝膠與生物組織的結構和性能比較相似，生物相容性和生物安全性好，被廣泛應用于組織工程、藥物輸送、創傷敷料等領域，具有非常廣闊的應用前景。發展具有高強韌性能和響應功能的高分子水凝膠，是近年來研究的熱點和難點。綜述了近 10 年來代表性的納米復合水凝膠、雙網絡水凝膠、響應型水凝膠等新型高分子水凝膠方面的重要研究進展，總結了其設計與合成的基本原理和方法，介紹了幾種典型的高強度和韌性高分子水凝膠的增強增韌機理和能量耗散機制，闡述了基于陽離子、陰離子及兩性離子單體的智能響應型高分子水凝膠的應激響應原理和特性。在此基礎上，分析討論了高強韌與響應型高分子水凝膠作為潛在生物材料仍需解決的關鍵科學問題，并對本領域的發展趨勢進行了展望。

Abstract:

Due to their similarities to bio-tissues, and excellent biocompatibility and biosafety, polymer hydrogels have been widely studied for potential applications in tissue engineering, drug delivery, and wound dressing, etc. The development of tough and responsive hydrogels has recently been a very hot topic with great challenges. In this review, progresses in the development of novel hydrogels including nanocomposite hydrogels, double network hydrogels and responsive hydrogels in last decade are reviewed. Several imporant design philosophy and synthesis method are accounted. The toughening mechanisms and energy dissipation mechanisms of a few representative strong and tough polymer hydrogels are introduced. Moreover, some smart and stimuli-responsive hydrogels based on cationic, anionic, and zwitteronic monomers are reviewed and discussed in detail. Based on these progresses, the major challenges of strong, tough, and responsive hydrogels as biomaterials are analyzed. Finally, the perspectives of tough and responsive hydrogels were discussed.