文章信息/Info

Title:

Applications of Synthetic Hydrogels in Tissue Engineering

作者:

 劉水蓮1; 宿烽1; 李速明2

 （1.青島科技大學 高性能聚合物研究院，山東 青島266042）
（2.法國蒙彼利埃二大歐洲薄膜研究院，蒙彼利埃 34095）

Author(s):

 LIU Shuilian1;  SU Feng1; LI Suming2

 1.Institute of High Performance Polymers, Qingdao University of Science and Technology, Qingdao 266042,China)
（ 2.Institut Europeen des Membranes, UMR CNRS 5635, Universite Montpellier II, Montpellier 34095)

關鍵詞:

合成水凝膠; 生物相容性; 機械性能; 組織工程

DOI:

10.7502/j.issn.1674-3962.2016.03.09

文獻標志碼:

A

摘要:

水凝膠材料因其高保濕、高吸水等特點，在組織工程、生物醫藥等領域具有廣闊的現實意義和應用前景，特別是作為藥物緩釋劑、組織填充劑、酶的包埋劑、人造皮膚等方面。按原料來源分，水凝膠材料可分為天然水凝膠材料和合成水凝膠材料。盡管天然水凝膠材料的生物相容性、生物降解性優于合成水凝膠材料，但合成水凝膠材料具有相對較高的機械性能，備受研究者青睞。近年來，如何將兩種類型的水凝膠材料的優點結合在一起應用成為研究熱點。大量關于水凝膠材料的改性研究相繼開展，并取得了一定進展。主要概述了以聚乙二醇、聚乙烯醇、聚丙烯酰胺為基礎合成的水凝膠材料的研究及發展狀況，并對幾種水凝膠材料進行了初步生物學評價，探討了此類水凝膠在組織工程中的應用。

Abstract:

Hydrogels have practical significance and broad application prospects in the field of tissue engineering , biomedicine, etc��, especially as drug delivery agents, tissue filling agent, enzyme�瞖mbedding agent and artificial skin, because of their high moisturizing ability and high water absorption. It can be divided into two types according to their raw material source, natural hydrogels and synthetic hydrogels. Although natural hydrogels have better biocompatibility, biodegradability than synthetic hydrogels, synthetic hydrogel materials have relatively high mechanical properties that attract researchers’ eyes. In recent years, it has become a research hotpot to combine the benefits of two types. A lot of researches on modification of hydrogels have emerged one after another, and some progress has made. This paper reviews the researches, development, biological evaluation of synthetic hydrogels based on poly(ethylene glycol), poly(vinyl alcohol), and polyacrylamide. Peculiar attention is paid to the applications in tissue engineering.