文章信息/Info

Title:

The Application Progress of Super�睵aramagnetic Iron Oxide Nanoparticles in Tumor Targeting Diagnosis and Treatment

作者:

 孫漢文; 張彥聰; 宋新峰; 孫春彥

 (德州學院醫藥與護理學院，山東 德州 253023)

Author(s):

 SUN Hanwen; ZHANG Yancong; SONG Xinfeng; SUN Chunyan

 (College of Medicine and Nursing, Dezhou University，Dezhou 253023,China)

關鍵詞:

氧化鐵; MRI; 造影劑; 靶向

DOI:

10.7502/j.issn.1674-3962.2016.03.10

文獻標志碼:

A

摘要:

超順磁性納米粒子(SPIONs)具有超順磁性、良好的生物相容性，在腫瘤的診斷和治療方面有很大潛力。腫瘤細胞表面會特異性的表達某些表面標志物，因此以磁性納米顆粒為核心的分子探針與腫瘤細胞表面的特異性分子標志物相結合, 可特異性的識別腫瘤并形成磁共振影像。SPIONs經特定的配體修飾，可賦予其組織器官靶向性，通過高滲透性以及外加磁場雙效靶向來提高藥物在腫瘤部位的生物利用度，從而減少對正常細胞的毒性，提高腫瘤局部的藥物濃度。SPIONs具有很高的磁熱效應，可通過導熱量殺死腫瘤細胞而被用于熱療，熱療較放療和化療的副作用小。因此功能化的SPIONs必將成為臨床深受歡迎的造影劑和基于MRI的診斷和治療試劑。總結了SPIONs在腫瘤診斷和治療方面的應用，同時探討SPIONs的性質、合成方法和表面修飾。

Abstract:

Superparamagnetic iron oxide nanoparticles (SPIONs) have shown immense potential to contrast agents for the magnetic resonance imaging diagnosis and cancer theranostics. There are specific expression of some surface markers in the tumor cell surface, so the molecule probe with magnetic nanoparticles as the core with a specific molecular markers on the surface of the tumor cells can identify the tumor and form a magnetic resonance imaging.The surface grafted with various targeting ligands affects the particles tissue distribution and pharmacokinetics. The bioavailability of drug in the tumor site is improved through the high permeability and doubled targeting magnetic field,reducing the toxicity to normal cells and increasing tumor local drug concentration.SPIONs have the very high magnetocaloric effect, which can kill tumor cells by heating, and the side effects are smaller than that of radiotherapy and chemothera.Functionalized SPIONs will become popular negative contrast materials for magnetic resonance imaging�瞓ased diagnosis and therapy. This review aims to focus on the ability of SPIONs used in the field of cancer diagnosis and targeting therapy as well as the synthesis,modification and the characteristics of SPIONs.