文章信息/Info

Title:

Research Development of the Biological Medical Silicone Rubber with Antimicrobial Properties

作者:

 劉芳; 胡琛

中南大學 粉末冶金國家重點實驗室

Author(s):

LIU Fang;   HU Chen

State Key Laboratory for Powder Metallurgy, Central South University

關鍵詞:

硅橡膠; 抗菌性; 表面改性; 本體改性

DOI:

10.7502/j.issn.1674-3962.2016.04.09

文獻標志碼:

A

摘要:

硅橡膠高分子材料具有優良的特性,如耐高溫、耐老化、透明度高，并且無毒無味、機械性能以及生物相容性好，因而廣泛應用于生物學、醫學等領域。然而隨著醫療水平的提高，人們對醫用制品的要求也越來越嚴格。硅橡膠植入生物體后易造成相關細菌感染，限制了其臨床應用。生物研究表明，通過表面改性和本體改性的方法，在硅橡膠中添加抗菌劑，可有效提高其抗菌性能, 抑制細菌的繁殖、防止二次感染的發生。通過對抗菌劑種類、含量等控制，可以使加工成型的液體或者固體硅橡膠保持原有的硫化和物理機械性能。通過總結國內外的研究成果，分析了各種生物醫用抗菌性硅橡膠材料，對其制備工藝、抗菌性能和應用情況等進行了闡述，同時也展望了新的研究思路。

Abstract:

The polymer material of silicone rubber has good properties, such as heat resistance, aging resistance, high transparency, avirulence, odorless, excellent mechanical property and biocompatibility. These kinds of materials are widely used in biological and medical fields. However, with the improvement of health standards, the demands for medical products continue to increase. Implanted into organisms, silicone rubber is likely to get infected by germs, which limits the clinical application of the materials. Some biological researchers show that, added antibacterial agent by surface modification and ontology modification, the antimicrobial properties of silicone rubber increase obviously. The addition of the antibacterial agents can inhibit microbial growth and prevent secondary infection. Controlling the types and contents of the antibacterial agents, the molding liquid silicone rubber or solid silicone rubber can keep original vulcanization, physical and mechanical properties. In this paper, preparation technology, antibacterial properties and application of antibacterial silicon rubbers are summarized. A new research idea is also discussed.