文章信息/Info

Title:

Research Development of Periosteum Tissue Engineering

作者:

宋菊青1; 2; 施雪濤1; 2; 王迎軍1; 2

(1.華南理工大學 國家人體組織功能重建與修復中心
(2.華南理工大學材料科學與工程學院

Author(s):

SONG Juqing 1; 2;  SHI Xuetao 1; 2;  WANG Yingjun 1; 2

(1.National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology,
(2.School of Materials Science and Engineering, South China University of Technology

關鍵詞:

骨缺損治療; 骨膜組織工程; 微圖案化; 血管化

DOI:

10.7502/j.issn.1674-3962.2016.06.10

文獻標志碼:

A

摘要:

一直以來，由創傷、腫瘤切除和先天畸形引起的臨界性骨缺損的臨床治療都存在極大的挑戰，包括自體骨移植在內的傳統骨缺損治療方法，由于供體不足和免疫排斥反應等問題，已經不足以滿足臨床需求。而組織工程的發展改變了骨修復的傳統治療模式，基于人工和天然生物材料的各種組織工程復合支架被用于修復受損骨。與此同時，也有越來越多的學者認識到骨膜在骨缺損修復中的重要作用，尤其是組織工程支架的整合性和血管化。除了自體或異體骨膜移植，研究者將組織工程的理念融入到骨膜修復中，從結構和功能上模擬天然骨膜。從組織工程骨膜的不同設計理念出發，簡單回顧了4類組織工程骨膜的研究進展，包括結構仿生型、微觀結構仿生型、血管化型和外力刺激型，這些將為骨組織工程構建和骨膜深入研究提供理論基礎并開啟新的思路和方法。

Abstract:

Always, the clinical therapy of critical�瞫ized bone defects caused by trauma, tumor removal surgery and congenital malformation undergoes great challenges. The traditional treatments for bone defects, including autografting, are unable to meet the clinical needs because of the shortage of donors and immunological rejection. The development of tissue engineering changes the traditional treatment modes, and various tissue engineering cell�瞓iomaterial composite scaffolds based on synthetic and natural biomaterials have been implemented to reconstruct injured bone. At the same time, more researchers aware the important role of periosteum in the bone defect healing, especially the integration and vascularization of the scaffold materials. Except the periosteum grafts (auto�瞣r allo��), researchers also provide a biomimetic methodology that integrates the concept of tissue engineering into the periosteum repair. A variety of periosteum tissue engineering have been proposed, which biomimic the native periosteum from structure or function. Here we simply review four types of functional tissue engineering periosteum, including structure biomimic, micro�瞫tructure biomimic, vascularization and mechanical stimulation, which would provide theoretical basis and open new opportunities for the construction of bone tissue engineering and the research of periosteum.