文章信息/Info

Title:

Application of Magetic Nanoparticles for Tumor-Targeting Hyperthemia

作者:

 謝俊1; 陳玲1; 嚴長志1; 楊文清1; 張宇1; 2; 顧寧1; 2

(1東南大學生物科學與醫學工程學院，江蘇省生物材料與器件重點實驗室，江蘇 南京 210009;
2蘇州國家納米科技2011協同創新中心 納米藥物與生物材料專業中心，江蘇 蘇州，215123)

Author(s):

 Xie Jun;  Chen Ling;  Yan Changzhi;  Yang Wenqing;  Zhang Yu;  Gu Ning

Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences & Medical Engineering, Southeast University

關鍵詞:

磁性納米材料; 靶向磁感應熱療; 療效; 制備; 表面修飾

DOI:

10.7502/j.issn.1674-3962.2016.08.01

文獻標志碼:

A

摘要:

結合磁性納米材料的腫瘤靶向磁感應熱療是近年來發展較快的一種腫瘤治療手段，因其療效確切、安全性高、副作用少，故可廣泛用于臨床腫瘤的治療。但是，如何實現經靜脈被動或主動靶向磁感應熱療并進一步提升治療效果面臨著重大挑戰，這需要進一步提升磁性納米顆粒的單分散性和交流磁熱效應、增加靶組織或靶細胞累積、聯合多靶點、多機制協同殺滅腫瘤細胞、聚焦磁感應加熱以及依賴于多模成像的精確引導等，其中蘊藏的基礎科學問題和關鍵核心技術急需突破。本文在介紹熱療用高性能磁性納米材料的制備及表面修飾研究概況的基礎上，對腫瘤靶向磁感應熱療當前的研究進展與技術發展的關鍵點進行探討，闡述了其優點和需要解決的問題，并對其未來的發展前景做了展望。

Abstract:

Magnetic nanoparticles (MNPs)-mediated targeted magnetic hyperthermia (TMH) is a rapid-developing tumor therapy in vivo. Based on its curative effect, high safety and less side effects, the therapy may widely receive enormous attention in further clinical applications. However, it has rather challenging in the MNPs-based passive or active targeted hyperthermia therapy by intravenously administration in vivo and their further enhanced therapy efficacy. In this regard, several basic scientific issues and key factors, such as the improved monodispersity of MNPs and their magnetic-induced heating effect, the increased MNPs accumulation in target tissues, the synergistic hyperthermia and chemotherapy effect, the focused heat induction and the multi-modal imaging-guided precise diagnostics, should be especially considered. Here we begin our review with the goal of describing controlled synthesis and surface modification of the MNPs with high performance, and then give a discussion on current key considerations in the MNPs-mediated TMH in vivo. Its superiority and disadvantages which are to be conquered are also described here. Finally, we get a perspective for its promising therapy in future clinical application.