文章信息/Info

Title:

Fluorescent Nanomaterials and Their Applications in Bioimaging

作者:

蒲  源; 王  丹; 錢  駿; 陳建峰

北京化工大學(xué)有機(jī)無機(jī)復(fù)合材料國家重點(diǎn)實(shí)驗(yàn)室，浙江大學(xué)現(xiàn)代光學(xué)儀器國家重點(diǎn)實(shí)驗(yàn)室

Author(s):

PU Yuan; WANG Dan; QIAN Jun; CHEN Jianfeng

State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology; State Key Laboratory of Modern Optical Instrumentations, Zhejiang University

關(guān)鍵詞:

熒光納米材料; 半導(dǎo)體量子點(diǎn); 碳基量子點(diǎn); 上轉(zhuǎn)換發(fā)光納米顆粒; 生物成像

Keywords:

fluorescent nanomaterials;  semiconductor quantum dots;  carbon dots; upconversion nanophosphors;  bioimaging

DOI:

10.7502/j.issn.1674-3962.2017.02.04

文獻(xiàn)標(biāo)志碼:

A

摘要:

熒光成像是生物醫(yī)學(xué)研究領(lǐng)域應(yīng)用最廣的成像技術(shù)之一。隨著納米技術(shù)的快速發(fā)展，具有優(yōu)良特性的熒光納米材料不斷涌現(xiàn)。相比于傳統(tǒng)的熒光分子，熒光納米材料具有光學(xué)穩(wěn)定性高、形貌尺寸易調(diào)控、多功能化等優(yōu)點(diǎn)。利用熒光納米材料作為探針的生物熒光成像能夠?yàn)檠芯空咛峁�從�?xì)胞、離體組織到活體生物樣本的結(jié)構(gòu)和動(dòng)態(tài)信息等方面全面細(xì)致的探測方法，成為當(dāng)前材料、光學(xué)、生物醫(yī)學(xué)等多學(xué)科交叉領(lǐng)域的研究熱點(diǎn)。結(jié)合近年來熒光納米材料及其生物成像應(yīng)用的發(fā)展趨勢以及本課題組前期的研究工作基礎(chǔ)，歸納概述了幾種類型熒光納米材料的特性，包括基于有機(jī)熒光染料的納米顆粒、半導(dǎo)體量子點(diǎn)、碳基熒光納米材料以及稀土摻雜上轉(zhuǎn)換發(fā)光納米材料，結(jié)合具體例子介紹了熒光納米材料在生物醫(yī)學(xué)成像中的應(yīng)用，并對其發(fā)展前景進(jìn)行了展望。

Abstract:

Fluorescence imaging is one of the most widely used imaging techniques in biomedical research. Along with the rapid development of nanotechnology, different kinds of fluorescent nanomaterials with excellent properties are constantly emerging. Compared to traditional fluorescent molecules, fluorescent nanomaterials show many advantages, such as superior photostability, tunable morphology and size, as well as multifunction. Fluorescence imaging based on nanomaterials offers a unique approach that can be used to visualize morphological details for bio-species, ranging from living cells to animals, forming a major thrust in the fields of materials, optics, biomedical and so on. In this article, we will present a focused review on various types of fluorescent nanomaterials, including organic dye doped nanoparticles, semiconductor quantum dots, and fluorescent carbon nanomaterials. The applications of these nanomaterials in bioimaging will be summarized with examples. We will also discuss some challenges and opportunities for the use of fluorescent nanomaterials in biomedical diagnosis and therapy.