文章信息/Info

Title:

Application of Nanomaterials in Photodynamic Therapy for Tumor

作者:

梁平平;  劉功遠(yuǎn); 董曉臣

南京工業(yè)大學(xué)先進(jìn)材料研究院 江蘇省柔性電子重點(diǎn)實(shí)驗(yàn)室、江蘇先進(jìn)生物與化學(xué)制造協(xié)同創(chuàng)新中心

Author(s):

LIANG Pingping;  LIU Gongyuan;  DONG Xiaochen

Key Laboratory of Flexible Electronics, Jiangsu National Synergetic Innovation Center for Advanced Materials, Institute of Advanced Materials, Nanjing Tech University,

關(guān)鍵詞:

光動(dòng)力治療; 腫瘤; 納米粒子; 光敏劑; 光; 單線態(tài)氧

Keywords:

photodynamic therapy;  tumor;  nanoparticles;  photosensitizer;  light;  singlet oxygen

DOI:

10.7502/j.issn.1674-3962.2017.02.02

文獻(xiàn)標(biāo)志碼:

A

摘要:

光動(dòng)力治療(PDT)，是由光敏劑（或者其納米粒子）介導(dǎo)，在光的作用下，使生物分子和細(xì)胞發(fā)生形態(tài)或功能上的變化，從而誘導(dǎo)組織細(xì)胞損傷及壞死，被稱為光敏化-氧化作用的一種非侵入治療手段。光敏劑納米粒子、光、單線態(tài)氧是光動(dòng)力療法的三個(gè)重要元素。目前，PDT在臨床上主要應(yīng)用于惡性腫瘤的治療，具有高選擇性、低毒性、微創(chuàng)性、靶向性好、重復(fù)治療、治療時(shí)間短、可與放療和化療協(xié)同作用等優(yōu)勢(shì)，在腫瘤治療領(lǐng)域具有非常廣泛的應(yīng)用前景。根據(jù)已有文獻(xiàn)對(duì)腫瘤的光動(dòng)力治療方法進(jìn)行了綜述，介紹了光敏劑（主要是納米粒子）和光動(dòng)力治療的研究現(xiàn)狀，展望了其未來(lái)發(fā)展方向。研究結(jié)果發(fā)現(xiàn)以光敏劑納米粒子為基礎(chǔ)的光動(dòng)力治療對(duì)腫瘤組織具有特異性吸收和滯留作用,特別對(duì)體積較小、淺表腫瘤療效顯著,對(duì)惡性腫瘤治療也有很好的輔助作用，在腫瘤治療領(lǐng)域具有廣闊的應(yīng)用前景。

Abstract:

Photodynamic therapy (PDT) is a kind of non-invasive treatment mediated by photosensitizer or its nanoparticles. Under the activation of light, the biological molecule and cell change in morphology or function, leading to cell damage and necrosis, which is also known as sensitizing light-oxidation. Photosensitizer nanoparticles, light, singlet oxygen are the vital components of PDT. At present, PDT is mainly used in the clinical treatment of malignant tumors due to its high selectivity, low toxicity, microtrauma, excellent targeting, repeated treatment, short treatment time, and it can be combined with radiotherapy and chemotherapy. In order to introduce the present situation and prospect the development of PDT, a systematic introduction about photosensitizer and PDT is presented based on the published literatures.The results show that photosensitizer nanoparticles based PDT have specific effects of penetration and retention on tumor tissue,particularly for small and shallow tumor.They also possess exciting auxiliary effect on malignant tumor. In short, PDT has broad application prospects in cancer therapy.