文章信息/Info

Title:

Current Status and Development of Pharmaceutical Iron Based Nanomaterials

作者:

陳博; 顧寧

東南大學(xué)生物科學(xué)與醫(yī)學(xué)工程學(xué)院江蘇省生物材料與器件重點實驗室，蘇州納米科技協(xié)同創(chuàng)新中心納米藥物與生物材料專業(yè)中心

Author(s):

CHEN Bo;  GU Ning

School of Biological Sciences & Medical Engineering，Southeast University Collaborative Innovation Center of Suzhou Nano-Science and Technology

關(guān)鍵詞:

鐵基納米材料; 藥用; 制備方法; 臨床研究; 發(fā)展前景

Keywords:

iron-based nanomaterial;  medicinal application;  preparation method;  clinical research;  development prospect

DOI:

10.7502/j.issn.1674-3962.2017.03.08

文獻(xiàn)標(biāo)志碼:

A

摘要:

鐵基納米材料是指以天然或人工方法得到的納米尺度范圍的鐵、鐵氧體及鐵合金等的功能性材料。根據(jù)結(jié)構(gòu)組成可分為超順磁性氧化鐵納米粒，磁性氧化鐵微球，磁性鐵蛋白，磁小體，磁性氧化鐵脂質(zhì)體及鐵合金納米粒等。鐵基納米材料具有優(yōu)良的尺寸效應(yīng)，表面效應(yīng)與量子效應(yīng)，尤為重要的是獨特的磁學(xué)性質(zhì)，使其在生物醫(yī)藥領(lǐng)域包括核磁共振造影、體外生物分離、腫瘤磁熱療，藥物遞送及組織工程等方面得到廣泛應(yīng)用，且已有產(chǎn)品被批準(zhǔn)上市或處于臨床試驗研究。理想的藥用鐵基納米材料應(yīng)具有結(jié)構(gòu)明確，性質(zhì)穩(wěn)定，高度分散，可規(guī)模化生產(chǎn)以及體內(nèi)應(yīng)用安全有效等特性。限制鐵基納米材料醫(yī)學(xué)應(yīng)用的問題在于鐵離子在體內(nèi)產(chǎn)生的氧化應(yīng)激反應(yīng)與鐵過載對機(jī)體的毒性。本文綜述了藥用鐵基納米材料的研究現(xiàn)狀以及面臨的機(jī)遇與挑戰(zhàn)，并展望了其發(fā)展前景。

Abstract:

Iron-based nanomaterial is made of nano-sized iron, iron oxide and ferroalloy by nature product or artificial synthesis. According to different structure composition, iron-based pharmaceutical nanomaterial can be classified into super paramagnetic iron oxide nanoparticles, magnetic iron oxide microspheres, magnetoferritin, magnetic iron oxide liposome, ferroalloy nanoparticle and etc. Iron-based nanomaterial has remarkable size effect, surface effect and quantum effect, especially unique magnetic properties, which makes it be widely used in magnetic resonance imaging, bioseparation in vitro, magnetic hyperthermia and drug delivery. Moreover, quite a few products have been approved in market or under clinical trials. Ideal iron-based nanomedicine should own important characteristic including definite structure, stable physical properties, uniform distribution, scalable production, safety and effectiveness in vivo. The drawbacks that confine medicinal application of iron-based nanomaterial depend on oxidative stress induced by iron ion and toxicity by iron overload in body. This article review research status of iron-based medicinal nanomaterial and the facing opportunities and challenges, finally give a prospects for the development.