文章信息/Info

Title:

Preparation and Controlled Release Performance of Magnetic Ordered Mesoporous CarbonNanospheres as Targeted Drug Carrier

作者:

鄭  靜; 陳  琳; 張  歡; 楊永珍; 劉旭光; 許并社

（1.太原理工大學 新材料界面科學與工程教育部重點實驗室，山西 太原 030024）（2.太原理工大學化學化工學院，山西 太原 030024）（3.太原理工大學 新材料工程技術研究中心，山西 太原 030024）（4.太原理工大學材料科學與工程學院，山西 太原 030024）

Author(s):

ZHENG Jing1; 2;  CHEN Lin1; 3;  ZHANG Huan1; 2; YANG Yongzhen1; 3;  LIU Xuguang1; 4;  XU Bingshe1; 3

(1.Key Laboratory of Interface Science and Engineering in Advanced Materials of Ministry of Education,Taiyuan University of Technology, Taiyuan 030024, China)(2.College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China)(3.Research Center on Advanced Materials Science and Technology, Taiyuan University of Technology, Taiyuan 030024, China)(4.College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China)

關鍵詞:

有序介孔納米碳; 磁靶向; 藥物緩釋; 控釋性能; 鹽酸阿霉素

Keywords:

ordered mesoporous carbon nanospheres;  magnetic targeting;  drug delivery;  controlled release;  doxorubicin hydrochloride

DOI:

10.7502/j.issn.1674-3962.2018.01.07

文獻標志碼:

A

摘要:

藥物的靶向控釋已成為腫瘤化療研究的熱點。以有序介孔納米碳球（OMCNs）為基質，先后對其進行磁化、氨基和肼基修飾，最終制得可與抗腫瘤藥物鹽酸阿霉素（DOX）共價結合的磁靶向藥物載體（HMOMCNs）。利用場發射掃描電子顯微鏡、X射線衍射分析儀、熱重分析儀、傅里葉變換紅外分析儀、紫外-可見分光光度計等分析手段對HMOMCNs進行結構表征和性能評價。結果顯示：HMOMCNs的粒徑約為100 nm左右，具有豐富的孔道結構，對DOX的最大載藥量為529.18 mg·g^-1；HMOMCNs對DOX具有pH控釋性，隨著pH的降低，其累積釋藥率增加，當pH降至5.5時，10 h累積釋藥率達到最大，最大值為76%。

Abstract:

The controlled release behavior of targeted drug delivery has attracted widespread concern. In this paper, magnetic targeted drug carrier (HMOMCNs), which can covalently bond to anti-cancer drug doxorubicin hydrochloride (DOX), was synthesized from ordered mesoporous carbon nanospheres (OMCNs) through magnetization, amination and hydrazine modification. The structural characterization and performance evaluation of HMOMCNs were carried out by field emission scanning electron microscopy, X-ray diffraction analyzer, thermogravimetric analyzer, Fourier transformation infrared spectroscopy and ultraviolet-visible spectrophotometer. The results showed that the HMOMCNs had a particle size of about 100 nm with good ordered mesoporous structure, and the maximum drug loading capacity was 529.18 mg·g^-1. The release of DOX from HMONCNs can be controlled by pH values. With the decrease of the pH value, the cumulative release rate increased. When pH was 5.5, the cumulative release rate was 76% and reached the equilibrium for about 10 h.