文章信息/Info

Title:

Research Process on the Lung Surfactant Microbubbles

作者:

 劉東; 楊芳; 顧寧

 東南大學生物科學與醫學工程學院，江蘇省生物材料與器件重點實驗室,  江蘇 南京210096

Author(s):

 LIU Dong;  YANG Fang;  GU Ning

 School of Biological Sciences and Medical Engineering, Southeast University, Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210096, China

關鍵詞:

 ; 微氣泡; 肺表面活性物質; 診療學; 超聲

Keywords:

microbubbles;  pulmonary surfactant;  theranostics;  ultrasound

DOI:

10.7502/j.issn.1674-3962.2017.06.08

文獻標志碼:

A

摘要:

 結合藥學、生物學、生物醫學工程、材料學等多學科，微氣泡超聲造影劑由于具有超聲顯影增強和藥物裝載功能，目前正朝著實現組織靶向分子成像、結合其他成像模式的多模態成像以及結合藥物或基因，集診斷與治療功能為一體的多模式、多功能方向發展。肺表面活性物質是存在于肺泡氣液交界面上的一種主要由磷脂和特異性蛋白質組成的脂蛋白復合物，具有降低肺泡表面張力，實現先天性免疫以及防止抗病原體入侵體內等功能。因此，由肺部表面活性物質作為膜殼層穩定形成的肺表面活性物質微氣泡是一種新型的兼具超聲成像和治療功能的藥物輸運系統，是研究熱點之一。本文系統綜述了微氣泡在醫學診療領域中的應用，以及近期肺表面活性物質微氣泡的研究進展，并對其在治療上的應用和發展前景進行了討論。

Abstract:

Combining with pharmacy, biology, biomedical engineering, materials science and other disciplines, microbubbles ultrasound contrast agents have the functions of enhanced ultrasound imaging and drug loading. So far microbubbles are moving towards to achieve the aim of tissue targeted molecular imaging and combined with multimodality imaging and other imaging mode, as well as unite drugs or genes. Pulmonary surfactant (PS) is a kind of lipid protein complex, located on the alveolar gas-liquid interface and mainly consisting of phospholipids and specific proteins. The function of PS is to reduce the surface tension of lung, realize the innate immunity and protect the invasion of pathogens. Microbubbles coated and stabilized by PS have been a topic of interest as a novel drug delivery system with ultrasound imaging and therapeutic functions. In the paper, the application of microbubbles in the fields of medical diagnosis and treatment is elaborated, the research process on PS microbubbles is introduced, and the prospects of application and development to PS microbubbles are also discussed.