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Title:: Recent advances in Biomacromolecule immobilization by metal organic frameworks

Author(s):: GU Na; LI Heng; ZHAO Yuan; School of Science, Hebei University of Science and Technology

Keywords:: Metal organic framework; Protein; Enzyme; Nucleic acid; Biomacromolecule; Immobilization

摘要:: 金屬有機骨架（MOFs）具有超高的比表面積、可調的孔徑、多樣的結構組成、開放的金屬位點和化學可修飾等性能。近年來，MOFs材料作為穩定的，高效的，可重復使用的和廉價的生物大分子的固定化載體越來越引起人們的研究興趣。生物大分子-MOFs體系在改進生物催化劑的效率及可回收性、分子傳感、藥物輸送和基因治療等方面具有廣闊的應用前景。本文總結了MOFs材料作為生物大分子固定化載體的應用進展。討論了生物大分子在MOFs載體材料上固定的方法和方式，生物大分子可以通過物理吸附或共價鍵作用固定在MOFs表面，或通過與配位基團發生親水或疏水作用擴散進入MOFs孔道，或通過共價鍵或配位鍵包埋在其晶體結構中。設計具有大孔徑的高介孔MOFs材料、設計不同的功能化MOFs材料及以環境友好的方式合成所需的生物大分子-MOFs體系等，可近一步擴大MOFs材料在生物大分子固定領域的應用范圍。

Abstract:: Metal organic frameworks (MOFs) with properties of high specific surface area, tunable porosity, controllable structure, open metal sites and desirable functionality, have been demonstrated as stable, robust, reusable, efficient, and cost effective substrates for biomacromolecule immobilization, which have motivated increasing research interest. Biomacromolecule-MOFs composites have extensive application in improvements of biocatalyst efficiency and promising recyclability, molecular sensing, drug deliver and gene therapy. This review focuses on the progress in the application of MOFs as biomacromolecule immobilization matrix and the method and mode for biomacromolecule immobilization to MOFs substrates. The biomacromolecule can be immobilized on the surface of MOFs by physical absorption or covalent bond, diffuse into the pore of MOFs by functional interactions with the MOF ligand moieties or be encapsulated within framework structure by covalent bond or coordination bond during mineralization of MOFs. The design of highly mesoporous and various functional MOFs and the eco-friendly synthesis of biomacromolecule-MOFs composites will enlarge the application range of MOFs as substrates for biomacromolecule immobilization.