文章信息/Info

Title:

Research progress in semiconductor-based photothermal nanoagents

作者:

王兆潔;  余諾;  孟周琪;  劉子瀟;  MACHARIA Daniel K.;  胡俊青;  陳志鋼

東華大學材料科學與工程學院，纖維材料改性國家重點實驗室

Author(s):

WANG Zhaojie;  YU Nuo;  MENG Zhouqi;  LIU Zixiao;  MACHARIA Daniel K.; HU Junqing;  CHEN Zhigang

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University

關鍵詞:

癌癥; 光熱治療; 光熱試劑; 半導體; 多功能

Keywords:

cancer;  photothermal therapy;  photothermal agent;  semiconductor;  multifunction

DOI:

10.7502/j.issn.1674-3962.2017.12.06

文獻標志碼:

A

摘要:

癌癥已成為嚴重威脅人們健康的頭號殺手，傳統的癌癥治療技術存在很多的局限和不足，所以亟需開發一種新型的治療技術。目前，近紅外光驅動的光熱消融治療已經被認為是一種有效的癌癥治療技術，該技術的發展關鍵是研發高效且生物相容性好的光熱轉換試劑。半導體光熱轉換試劑具有價格低廉、光熱轉換效率高等優點，引起了廣泛關注。本文總結了近年來半導體光熱轉換試劑的研究進展，主要包括銅基（CuS, Cu9S5和CuSe等）和鎢基（W18O49, CsxWO3和WS2等）半導體。另外，還介紹了半導體多功能光熱試劑（如G-CuS-DOX和FeS2-350等）在化療/熱療或者成像/治療一體化方面的進展。最后，指出了目前存在的問題和發展方向。

Abstract:

Cancer is a worldwide leading cause of death. Conventional therapeutic techniques for cancers have some obvious limitations and are unsatisfactory, thus it is very necessary to develop new therapy technology. Recently, near-infrared (NIR) laser-induced photothermal ablation therapy (PAT) has been demonstrated to have great potential to cure tumors, and a prerequisite is to obtain biocompatible and efficient photothermal agents. Among all the photothermal agents, semiconductor-based photothermal nanoagents have attracted increasing interest due to their low cost and high photothermal conversion efficiency. This review attempts to summarize the recent progress in the rational design and fabrication of semiconductor photothermal nanoagents, including Cu-based (CuS, Cu9S5 and CuSe) and W-based (W18O49, CsxWO3 and WS2) nanomaterials. Furthermore, the semiconductor-based multifunction nanoagents (such as G-CuS-DOX, FeS2-350) are also summarized for the development of synergic photothermal/chemo-therapy or imaging-guided photothermal therapy. This review ends with a summary and some perspectives on the challenges and new directions in this exciting and still emerging area of research.